Results 121 to 130 of about 232,874 (323)

Azole-resistant Aspergillus fumigatus harboring TR34/L98H, TR46/Y121F/T289A and TR53 mutations related to flower fields in Colombia

Scientific Reports, 2017
Resistance to triazoles in Aspergillus fumigatus has been reported in azole-naive patients in Europe, Asia, Australia and North America. This resistance has been linked to fungicide-driven mutations in the cyp51A gene and its promoter region.
C. Alvarez-Moreno, R. Lavergne, F. Hagen, F. Morio, J. Meis, P. Le Pape   +5 more
semanticscholar   +1 more source

Microfluidic live‐cell imaging of Aspergillus fumigatus and Candida albicans hyphal growth treated with AmBisome and Caspofungin

Journal of Microscopy, EarlyView.
Abstract Hyphal forms of human pathogenic fungi cause invasive disease in humans, but the hyphal response to antifungals is understudied. In the major fungal pathogens Aspergillus fumigatus and Candida albicans, we used microfluidic‐coupled, fluorescence‐mediated live‐cell imaging to capture the real‐time responses of fungal hyphae to clinical ...
D. D. Thomson, R. Inman, S. Nye, E. M. Bignell   +3 more
wiley   +1 more source

A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions

PLoS Pathogens, 2017
Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an increasing incidence of drug resistance. This situation is further complicated by the finding that strains resistant to azoles, the major antifungal drugs for ...
Daisuke Hagiwara, Miura Daisuke, Kiminori, Shimizu, S. Paul, Ayumi Ohba, T. Gonoi, A. Watanabe, K. Kamei, T. Shintani, W. Scott Moye-Rowley, S. Kawamoto, K. Gomi, R. Cramer   +13 more
semanticscholar   +1 more source

An Improved Description of the Small RNA Landscape of the Human Fungal Pathogen Aspergillus fumigatus

Molecular Microbiology, EarlyView.
The mechanisms of small RNA biogenesis in fungi are diverse and multifactorial. Here, we provide an improved understanding of the processing of double‐stranded RNA in the human fungal pathogen Aspergillus fumigatus, revealing susceptibility to high levels of double‐stranded RNA and limited input of the canonical RNAi machinery on the endogenous small ...
Xiaoqing Pan, Abdulrahman A. Kelani, Lukas Schrettenbrunner, Swatika Prabakar, Bhawana Israni, Matthew G. Blango   +5 more
wiley   +1 more source

Central nervous system Aspergillus fumigatus infection with subarachnoid haemorrhage secondary to hemophagocytic lymphohistiocytosis: a rare case report

BMC Neurology
Background Secondary central nervous system (CNS) Aspergillus fumigatus infection leading to subarachnoid hemorrhage following the onset of hemophagocytic lymphohistiocytosis (HLH) represents an extremely rare case.
Siting Wu, Ning Zhao, Yunxing Liang, Weinan Zhang, Fang Cui, Jiacai Lin   +5 more
doaj   +1 more source

APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis. [PDF]

, 2019
Invasive pulmonary aspergillosis (IPA) due to Aspergillus fumigatus is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new antifungal agents, mortality rates remain high, and new treatments are needed ...
Alkhazraji, Sondus, Alqarihi, Abdullah, Gebremariam, Teclegiorgis, Gu, Yiyou, Ibrahim, Ashraf S, Jeon, Heewon H, Kapoor, Mili, Shaw, Karen J   +7 more
core  

The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. [PDF]

, 2012
BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been implicated in the pathogenesis of cardiovascular disease.
Fehrenbach, Melane L, Haczku, Angela, Jiang, Zhilong, Kokalari, Blerina, Macphee, Colin, Ravaioli, Giulia, Redai, Imre G, Sheardown, Steven A, Wilson, Stephen   +8 more
core   +2 more sources

Aspergillus fumigatus and Aspergillus flavus-Specific IgG Cut-Offs for the Diagnosis of Chronic Pulmonary Aspergillosis in Pakistan [PDF]

, 2020
Kauser Jabeen, Joveria Farooqi, Nousheen Iqbal, Khalid Wahab, Muhammad Irfan   +4 more
openalex   +1 more source

A Novel Environmental Azole Resistance Mutation in Aspergillus fumigatus and a Possible Role of Sexual Reproduction in Its Emergence

mBio, 2017
This study investigated the dynamics of Aspergillus fumigatus azole-resistant phenotypes in two compost heaps with contrasting azole exposures: azole free and azole exposed.
Jianhua Zhang, E. Snelders, B. Zwaan, Sijmen E. Schoustra, J. Meis, K. van Dijk, F. Hagen, M. T. van der Beek, G. Kampinga, J. Zoll, W. Melchers, P. Verweij, A. Debets   +12 more
semanticscholar   +1 more source

Long‐term stability of sinus complication management

Periodontology 2000, EarlyView.
Abstract Maxillary sinus augmentation shows a low incidence of complications and high clinical success due to favorable biological conditions and typically transient issues. Most complications are intraoperative, such as Schneiderian membrane perforation or hemorrhage, and are often resolved immediately.
Pablo Galindo‐Moreno, Tiziano Testori, Miguel Padial‐Molina, Allinson Olaechea, Francisco O'Valle, Pablo Galindo‐Fernandez   +5 more
wiley   +1 more source