Emerging threat of triazole-resistant Aspergillus fumigatus
Invasive aspergillosis is a leading cause of morbidity and mortality among immunocompromised populations and is predicted to cause more than 200 000 life-threatening infections each year. Aspergillus fumigatus is the most prevalent pathogen isolated from
J. Rybak, J. Fortwendel, P. Rogers
semanticscholar +1 more source
Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry
Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten +5 more
wiley +1 more source
This work developed a PDC nanoplatform that orchestrated a multimodal synergistic therapy, combining active targeting, photothermal therapy, and iron nutrient deprivation. The antifungal, anti‐inflammatory efficacy and corneal repair ability of nanoplatform were demonstrated through both in vitro and in vivo evaluations.
Ruojiao Feng +13 more
wiley +1 more source
Prevalence, persistence, and phenotypic variation of Aspergillus fumigatus in the outdoor environment in Manchester, UK, over a 2-year period [PDF]
Fadwa Alshareef, Geoffrey D. Robson
openalex +1 more source
ABSTRACT Lemongrass essential oil (LGEO) has gained recognition as a natural preservative in food systems due to its distinctive phytochemical composition and multifunctional bioactivities. Dominated by citral and complemented by terpenes and phenolic compounds, LGEO demonstrates potent antibacterial, antifungal, antiviral, antibiofilm, and antioxidant
Ahmad Rabbani +4 more
wiley +1 more source
Studies on the release of neutrophil extracellular traps and IFN-γ as part of the innate immune response to Aspergillus fumigatus and on the fungal stress response via the hybrid sensor kinase TcsC [PDF]
Aspergillus fumigatus is a saprophytic mold that naturally inhabits the soil. Asexual reproduction yields hardy conidia that circulate in the air and are inhaled daily by humans.
McCormick, Allison
core
ABSTRACT Long terminal repeat retrotransposons (LTR‐RTs) are recognised as a significant evolutionary force capable of shaping the structure and function of the genomes in eukaryotes, including animals, plants, and fungi. However, much remains largely unknown about how LTR‐RTs influence the evolution of fungi at the chromosomal level.
Chengyu Gao +4 more
wiley +1 more source
Effect of Aflatoxin on Phagocytosis of Aspergillus fumigatus Spores by Rabbit Alveolar Macrophages [PDF]
J. L. Richard, John R. Thurston
openalex +1 more source
The domestic pig as human‐relevant large animal model to study adaptive antifungal immune responses against airborne Aspergillus fumigatus [PDF]
Stefanie Schmidt +14 more
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In the LEAD cohort, micro‐arrayed asthma allergens identified IgE‐sensitized adult asthma patients. Compared to non‐IgE‐sensitized patients, they had better lung function, took less ICS and had lower eosinophils. IgE‐sensitized patients were sensitized to a handful of respiratory allergen sources and may benefit from allergen‐specific forms of ...
Huey‐Jy Huang +20 more
wiley +1 more source

