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Molecular genetics in Aspergillus fumigatus
Current Opinion in Microbiology, 2000Manipulation of the genome of the human pathogen Aspergillus fumigatus is not well developed. Approaches and data from related model organisms are being used to develop molecular genetic systems in A. fumigatus; for example, the molecular typing of strains during infection.
Brookman, Jayne L., Denning, David W.
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Sequencing the Aspergillus fumigatus genome
The Lancet Infectious Diseases, 2002Aspergillus fumigatus is the most common mould pathogen of human beings and unusually causes both invasive disease in immunocompromised patients and allergic disease in patients with atopic immune systems. 4% of patients dying in modern European teaching hospitals have invasive aspergillosis and it is the leading infectious cause of death in leukaemia ...
Denning, David W. +4 more
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The pathobiology of Aspergillus fumigatus
Trends in Microbiology, 2001Aspergillus fumigatus is the most prevalent airborne fungal pathogen in developed countries, and in immunocompromised patients causes a usually fatal invasive aspergillosis (IA). Understanding the pathobiology of this fungal species requires not only analysis of the putative fungal virulence factors that stimulate fungal growth and/or survival in the ...
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Serological studies on Aspergillus fumigatus
Mycopathologia et Mycologia Applicata, 19611) Extract was obtained by repeated cryolysis of acetone-dried mycelia ofAsp. fumigatus killed by formalin. High titer immune serum could be easily obtained by immunizing rabbits with this extract.
Masao Fukui, Junichi Yasuda
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Metabolism of progesterone by Aspergillus fumigatus
Journal of Steroid Biochemistry, 1982Abstract Metabolism of progesterone by a typical strain of Aspergillus fumigatus was studied. The four metabolites isolated were characterized as 5α-pregnane-3s-ol-20-one, 15s-hydroxy-1,4-pregnadiene-3,20-dione, 7s,15s-dihydroxy-4-pregnene-3,20-dione and 11α,15s-dihydroxy-4-pregnene-3,20-dione by the application of various spectrometric techniques.
Shashi B. Mahato +2 more
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Production of melanin by Aspergillus fumigatus
Journal of Medical Microbiology, 2004Melanins, or melanin-like compounds, may play a role in the pathogenesis of a number of human fungal infections. This study investigated the production of melanin by the important opportunistic pathogen Aspergillus fumigatus. Conidia from A. fumigatus were harvested and treated with proteolytic enzymes, denaturant and hot, concentrated acid; this ...
Youngchim, S +3 more
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Aspergillus fumigatus DHN-Melanin
2020Dihydroxynaphthalene melanin (DHN-melanin) is an integral component of the conidial cell wall surface, which has a central role in the pathogenicity of the major human airborne fungal pathogen Aspergillus fumigatus. Although the biosynthetic pathway for A.
Georgios Chamilos, Agostinho Carvalho
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The virulence of Aspergillus fumigatus [PDF]
, 2007 The aim of this chapter is to analyze Aspergillus fumigatus virulence in light of recent developments in genomics and our growing understanding of the complexity of the host–pathogen interaction. Readers interested in comprehensive summaries describing putative virulence determinants of A.
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Insertional mutagenesis of Aspergillus fumigatus
Molecular and General Genetics MGG, 1998We have investigated transformation with heterologous DNA as a method for insertional mutagenesis of Aspergillus fumigatus. Two methods, polyethylene glycol-mediated transformation of protoplasts and electroporation of germinating spores, were used to establish conditions leading to single-copy integration of transforming DNA at different genomic sites.
A. Aufauvre-Brown +2 more
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Developmental regulators in Aspergillus fumigatus
Journal of Microbiology, 2016The filamentous fungus Aspergillus fumigatus is the most prevalent airborne fungal pathogen causing severe and usually fatal invasive aspergillosis in immunocompromised patients. This fungus produces a large number of small hydrophobic asexual spores called conidia as the primary means of reproduction, cell survival, propagation, and infectivity.
Jae-Hyuk Yu, Hee-Soo Park
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