Results 241 to 250 of about 184,097 (275)

CAR T cells targeting Aspergillus fumigatus are effective at treating invasive pulmonary aspergillosis in preclinical models

Science Translational Medicine, 2022
Aspergillus fumigatus is a ubiquitous mold that can cause severe infections in immunocompromised patients, typically manifesting as invasive pulmonary aspergillosis (IPA). Adaptive and innate immune cells that respond to A.
Michelle Seif, T. K. Kakoschke, F. Ebel, M. Bellet, Nora Trinks, G. Renga, M. Pariano, L. Romani, Beeke Tappe, D. Espie, E. Donnadieu, Kerstin Hünniger, A. Häder, Markus Sauer, D. Damotte, M. Alifano, P. L. White, M. Backx, T. Nerreter, M. Machwirth, O. Kurzai, Sabrina Prommersberger, H. Einsele, M. Hudecek, J. Löffler   +24 more
semanticscholar   +1 more source

Aspergillus fumigatus and pan-azole resistance: who should be concerned?

Current Opinion in Infectious Diseases, 2020
PURPOSE OF REVIEW Although clinical outcomes in the treatment of aspergillosis have markedly improved with the availability of newer triazoles, the development of resistance to these antifungals, especially in Aspergillus fumigatus, is a growing concern.
N. Wiederhold, P. Verweij
semanticscholar   +1 more source

Genomics of Aspergillus fumigatus

Revista Iberoamericana de Micología, 2005
Aspergillus fumigatus is a filamentous fungal saprophyte that is ubiquitous in the environment. It is also a human pathogen and induces allergenic response, negatively impacting health care and associated costs significantly around the world. Much of the basic biology of this organism is only poorly understood, but the recent completion and publication
Ronning, Catherine M., Fedorova, Natalie D., Bowyer, Paul, Coulson, Richard, Goldman, Gustavo, Kim, H. Stanley, Turner, Geoffrey, Wortman, Jennifer R., Yu, Jiujiang, Anderson, Michael J., Denning, David W., Nierman, William C.   +11 more
openaire   +4 more sources

Metabolites of Aspergillus fumigatus

China Journal of Chinese Materia Medica, 2012
Aspergillus fumigatus, a type of endophytic fungi from Erthrophleum fordii, was fermented with GPY culture medium. Fermented liquid and mycelium were extracted from fermented products after freezing and thawing treatment. After alcohol extraction, mycelium was extracted with ethyl acetate and n-butyl alcohol, respectively.
Shi-Shan Yu, Guang-Zhi Ding, Shuang-Gang Ma, Yun-Bao Liu   +3 more
openaire   +2 more sources

Itraconazole resistance in Aspergillus fumigatus [PDF]

Antimicrobial Agents and Chemotherapy, 1997
Invasive aspergillosis is an increasingly frequent opportunistic infection in immunocompromised patients. Only two agents, amphotericin B and itraconazole, are licensed for therapy. Itraconazole acts through inhibition of a P-450 enzyme undertaking sterol 14alpha demethylation.
Denning, David W., Venkateswarlu, K., Oakley, Karen L., Anderson, M. J., Manning, N. J., Stevens, David A., Warnock, David W., Kelly, Steven L.   +7 more
openaire   +3 more sources

Aspergillus fumigatus scleritis

Acta Ophthalmologica Scandinavica, 1995
ABSTRACT We report a case of scleritis caused by Aspergillus fumigatus. The infection was successfully treated with antifungal drugs, cryotherapy and dura mater grafting. A 67‐year‐old man developed a scleral ulcer 2 months after suffering a trauma in his right eye caused by the branch of a tree.
M. V. De Rojas Silva, M. S-Salorio, M. Pereiro, G. Gallegos Chamas, B. Fente Sampayo, M. T. Rodriguez-Ares   +5 more
openaire   +3 more sources

Resistance of Aspergillus fumigatus to Itraconazole

Scandinavian Journal of Infectious Diseases, 1998
ment with the drug. The author concluded that the A. fumigatus strains acquired resistance to itraconazole during or following treatment. The author, however, failed to determine whether or not the isolates cultured from the sputa were genotypically identical. Although invasive infections by Aspergillus species are generally caused by a single genotype
Verweij, P.E., Voss, A., Meis, J.F.G.M.
openaire   +4 more sources

Immunity and tolerance to Aspergillus fumigatus.

Novartis Foundation symposium, 2006
The inherent resistance to diseases caused by Aspergillus fumigatus suggests the occurrence of regulatory mechanisms that provide the host with adequate defence without necessarily eliminating the fungus or causing unacceptable levels of host damage. Efficient responses to the fungus require different mechanisms of immunity.
MONTAGNOLI, Claudia, BOZZA, Silvia, Gaziano R, ZELANTE, TERESA, BONIFAZI, PIERLUIGI, MORETTI, SILVIA, BELLOCCHIO, Silvia, PITZURRA, Lucia, ROMANI, Luigina   +8 more
openaire   +5 more sources

Molecular genetics in Aspergillus fumigatus

Current Opinion in Microbiology, 2000
Manipulation of the genome of the human pathogen Aspergillus fumigatus is not well developed. Approaches and data from related model organisms are being used to develop molecular genetic systems in A. fumigatus; for example, the molecular typing of strains during infection.
Brookman, Jayne L., Denning, David W.
openaire   +4 more sources

Metabolomics ofAspergillus fumigatus

Medical Mycology, 2009
Aspergillus fumigatus is the most important species in Aspergillus causing infective lung diseases. This species has been reported to produce a large number of extrolites, including secondary metabolites, acids, and proteins such as hydrophobins and extracellular enzymes.
Kristian Fog Nielsen, Thomas Ostenfeld Larsen, Jens Christian Frisvad, Christian Rank   +3 more
openaire   +3 more sources