Results 21 to 30 of about 225,540 (315)
Frontiers in Fungal Biology, 2022 Invasive aspergillosis is a deadly fungal disease; more than 400,000 patients are infected worldwide each year and the mortality rate can be as high as 50-95%.
Alec Brown +8 more
doaj +1 more source
The Volatome of Aspergillus fumigatus [PDF]
Eukaryotic Cell, 2014 ABSTRACT Early detection of invasive aspergillosis is absolutely required for efficient therapy of this fungal infection. The identification of fungal volatiles in patient breath can be an alternative for the detection of Aspergillus fumigatus that still remains problematic.
Jean-Paul Latgé +2 more
openaire +3 more sources
Role of Hydrophobins in Aspergillus fumigatus [PDF]
Journal of Fungi, 2017 Resistance of Aspergillus fumigatus conidia to desiccation and their capacity to reach the alveoli are partly due to the presence of a hydrophobic layer composed of a protein from the hydrophobin family, called RodA, which covers the conidial surface. In A. fumigatus there are seven hydrophobins (RodA–RodG) belonging to class I and III.
John G. Gibbons +12 more
openaire +4 more sources
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus
Nature Communications, 2020 The frequency of antifungal resistance, particularly to the azole class of ergosterol biosynthetic inhibitors, is a growing global health problem. Survival rates for those infected with resistant isolates are exceptionally low. Beyond modification of the
Takanori Furukawa +22 more
semanticscholar +1 more source
Catalases of Aspergillus fumigatus [PDF]
Infection and Immunity, 2003 ABSTRACT Upon infection of a host, the pathogenic fungus Aspergillus fumigatus is attacked by the reactive oxygen species produced by phagocytic cells. Detoxification of hydrogen peroxide by catalases was proposed as a way to overcome this host response. A.
Richard D. Diamond +6 more
openaire +3 more sources
PREDICTION OF ANTIFUNGAL ACTIVITY OF 1,2,4-TRIAZOLE DERIVATIVES USING QSAR MODELS
Siberian Journal of Life Sciences and Agriculture, 2023 Purpose. Development of QSAR models and investigation of their effectiveness for predicting the antifungal activity of 1,2,4-triazole derivatives against Aspergillus flavus, Aspergillus fumigatus and Trichophyton mentagrophytes. Materials and methods.
Alexander L. Osipov
doaj +1 more source
On the lineage of Aspergillus fumigatus isolates in common laboratory use.
Medical Mycology, 2020 The origin of isolates routinely used by the community of Aspergillus fumigatus researchers is periodically a matter of intense discussion at our centre, as the construction of recombinant isolates have sometimes followed convoluted routes, the ...
M. Bertuzzi +5 more
semanticscholar +1 more source
Journal of Fungi, 2022 The antifungal resistance in non-fumigatus Aspergillus spp., as well as Aspergillus fumigatus, poses a major therapeutic challenge which affects the entire healthcare community.
Sanaz Nargesi +5 more
doaj +1 more source
Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies [PDF]
, 2015 Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. Schäfer for pilot experiments, and Emilia Mellado for strains. All authors acknowledge financial support of Gilead Sciences through Ph.D.
Gow, Neil A R +3 more
core +1 more source
Mechanisms of Triazole Resistance in Aspergillus fumigatus.
Environmental Microbiology, 2020 The ubiquitous fungal pathogen Aspergillus fumigatus is the primary cause of opportunistic mold infections in humans. Aspergilli disseminate via asexual conidia passively traveling through air currents to germinate within a broad range of environs ...
Ashley V. Nywening +3 more
semanticscholar +1 more source