Results 31 to 40 of about 39,957 (158)

Aspergillus, un asesino desconocido

Acta Neurológica Colombiana, 2021
El Aspergillus es un moho oportunista, que se encuentra muy extendido en el medio ambiente. Las cepas de A. fumigatus, A. Flavus, A. Niger y otras especies de Aspergillus pueden habitar diferentes tipos de ambientes.
José Enrique Vargas Manotas, Joaquín Fernando Vélez Ascanio, Nashla Andrea Chalela Blanco   +2 more
doaj   +1 more source

Regulation of gliotoxin biosynthesis and protection in Aspergillus species.

PLoS Genetics, 2022
Aspergillus fumigatus causes a range of human and animal diseases collectively known as aspergillosis. A. fumigatus possesses and expresses a range of genetic determinants of virulence, which facilitate colonisation and disease progression, including the
Patrícia Alves de Castro, Ana Cristina Colabardini, Maísa Moraes, Maria Augusta Crivelente Horta, Sonja L Knowles, Huzefa A Raja, Nicholas H Oberlies, Yasuji Koyama, Masahiro Ogawa, Katsuya Gomi, Jacob L Steenwyk, Antonis Rokas, Relber A Gonçales, Cláudio Duarte-Oliveira, Agostinho Carvalho, Laure N A Ries, Gustavo H Goldman   +16 more
doaj   +1 more source

Additivity interactions between fluconazole and citrus essential oils to Aspergillus fumigatus

Journal of Pre-Clinical and Clinical Research, 2021
Introduction Aspergillus fumigatus is the most common pathogen causing allergic bronchopulmonary mycosis. The pathogenic capacity of Aspergillus fumigatus is related to its thermal tolerance and the small size of the ...
Paula Wróblewska-Łuczka, Jarogniew Łuszczki   +1 more
doaj   +1 more source

Non-fumigatus Aspergillus-associated pulmonary events: a diagnostic challenge

Journal of Clinical Microbiology
Diagnosing pulmonary diseases caused by non-fumigatus Aspergillus species remains challenging. We conducted a single-center, retrospective observational study in a French Respiratory Medicine Department.
Cendrine Godet, Valentin Joste, Jean-Pierre Frat, Antoine Khalil, Vincent Bunel, Tiphaine Goletto, Thomas Maitre, Armelle Marceau, Domitille Mouren, Lise Morer, Mathilde Salpin, Gaëlle Weisenburger, Camille Taillé, Jacques Cadranel, Hervé Mal, Christine Bonnal   +15 more
doaj   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Gliotoxin, a Known Virulence Factor in the Major Human Pathogen Aspergillus fumigatus, Is Also Biosynthesized by Its Nonpathogenic Relative Aspergillus fischeri

mBio, 2020
Aspergillus fumigatus is a major opportunistic human pathogen. Multiple traits contribute to A. fumigatus pathogenicity, including its ability to produce specific secondary metabolites, such as gliotoxin.
Sonja L. Knowles, Matthew E. Mead, Lilian Pereira Silva, Huzefa A. Raja, Jacob L. Steenwyk, Gustavo H. Goldman, Nicholas H. Oberlies, Antonis Rokas   +7 more
doaj   +1 more source

Robots and Minimal, Physics‐Informed Features: A Hybrid Framework for Enzyme Catalysis

Advanced Science, EarlyView.
Robotic experimentation and physics‐informed machine learning combine to predict enzyme substrate scope. With a handful of interpretable features derived from docking and quantum mechanics calculations, our model rivals descriptor‐heavy AI approaches and extrapolates to unseen substrates and enzyme classes.
Natalia Onishchenko, Eric S. Larsen, Govind Paneru, Kisung Lee, Diana V. Kolygina, Yankai Jia, Elizabeth Maria Clarissa, Wai‐Shing Wong, Bartosz A. Grzybowski   +8 more
wiley   +1 more source

Environmental Hotspots for Azole Resistance Selection of Aspergillus fumigatus, the Netherlands

Emerging Infectious Diseases, 2019
Azole resistance is a major concern for treatment of infections with Aspergillus fumigatus. Environmental resistance selection is a main route for Aspergillus spp. to acquire azole resistance.
Sijmen E. Schoustra, Alfons J.M. Debets, Antonius J.M.M. Rijs, Jianhua Zhang, Eveline Snelders, Peter C. Leendertse, Willem J.G. Melchers, Anton G. Rietveld, Bas J. Zwaan, Paul E. Verweij   +9 more
doaj   +1 more source

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source