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Hypersensitivity pneumonitis of a bagpipe player: Fungal antigens as trigger?
Here we present a 79-year old man with chronic hypersensitivity pneumonitis probably caused by fungal contamination of a bagpipe. Several samples were taken from the patient's bagpipe.
Katharina Ziegler +5 more
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Fungal-specific IgG responses in allergic conjunctivitis: comparison with IgE and immunological implications [PDF]
Background Immunoglobulin G (IgG) is the most abundant antibody class in the bloodstream and is characterized by a long half-life compared to other immunoglobulins.
Tatsuya Mimura
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Microfluidic and MEMS-Based Biosensing Platforms for Fungal Respiratory Infections in Immunocompromised Patients: Toward Rapid, Specific, and Minimally Invasive Diagnosis [PDF]
Invasive fungal respiratory infections (IFRIs) remain a major cause of morbidity and mortality among immunocompromised patients, yet diagnosis continues to be hindered by nonspecific clinical features, limited sample accessibility, and the poor ...
Vasiliki E. Georgakopoulou +1 more
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Biomarkers in the Diagnosis of Aspergillosis [PDF]
Aspergillosis is a group of different invasive and non-invasive diseases affecting the lung and other organs, caused by species of the genus Aspergillus.
Laura Rivera-Agudelo +5 more
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Immunological assays based on the detection of circulating fungal biomarkers are helpful in clinical practice for diagnosing invasive fungal infections. Some of these targeting antigenic components are common to several different fungi. Histoplasmosis is
Juan David Puerta-Arias +2 more
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A fungal antigenic driver for Löfgren’s syndrome sarcoidosis [PDF]
Löfgren’s syndrome is an acute form of sarcoidosis that is characterized by the activation of CD4+ T helper cells. In this issue of JEM, Greaves et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210785) identified a peptide derived from an airborne mold species that stimulates T cells of Löfgren’s syndrome patients in an HLA-DR3–restricted manner.
Clarice X. Lim, Thomas Weichhart
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Novel Pneumocystis Antigens for Seroprevalence Studies
Pneumocystis jirovecii is the most common cause of fungal pneumonia in children under the age of 2 years. However, the inability to culture and propagate this organism has hampered the acquisition of a fungal genome as well as the development of ...
Dora Pungan +8 more
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Mannans are polysaccharide antigens expressed on the cell wall of different fungal species including Saccharomyces cerevisiae and Candida spp. These fungi are components of the normal intestinal microflora, and the presence of antibodies to fungal ...
Vadim B. Krylov +8 more
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Patients suffering from coronavirus disease-2019 (COVID-19) are susceptible to deadly secondary fungal infections such as COVID-19-associated pulmonary aspergillosis and COVID-19-associated mucormycosis.
Beeke Tappe +22 more
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Allergic Diseases Caused by Aspergillus Species in Patients with Cystic Fibrosis
Aspergillus spp. are spore forming molds; a subset of which are clinically relevant to humans and can cause significant morbidity and mortality. A.
Aidan K. Curran, David L. Hava
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