Results 71 to 80 of about 186,086 (280)

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Aspergillus fumigatus spondylitis in an immunocompetent patient with annular high signal around the intervertebral disks: a case report and literature review

Frontiers in Medicine
Aspergillus fumigatus spondylitis is a rare fungal infection, primarily occurring in immunocompromised patients, although cases in immunocompetent individuals have also been reported.
Zhihao Xu, Weijian Zhu, Sirui Zhou, Yuting Zhao, Qi Xiang, Yi Zhang   +5 more
doaj   +1 more source

In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR120) in Aspergillus fumigatus cyp51A, Denmark

Emerging Infectious Diseases, 2019
We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A.
R. Hare, J. B. Gertsen, K. Astvad, K. Degn, A. Løkke, M. Stegger, P. Andersen, Lise Kristensen, M. Arendrup   +8 more
semanticscholar   +1 more source

Microplastics in Agricultural Soil: Fate, Impacts, and Bioremediation by Earthworms

Journal of Plant Nutrition and Soil Science, EarlyView.
Microplastics enter the soil through various means, including the degradation of plastic film mulch, waste from cosmetics industries and municipalities, and the use of bioplastic seed coatings. These microplastics disrupt soil structure, microbial activity, enzyme function, and plant growth.
Sami ur Rehman, Mudassar Hussain, Federica De Castro, Michele Benedetti, Alessio Aprile, Francesco Paolo Fanizzi   +5 more
wiley   +1 more source

The Fungal Exopolysaccharide Galactosaminogalactan Mediates Virulence by Enhancing Resistance to Neutrophil Extracellular Traps. [PDF]

PLoS Pathogens, 2015
Of the over 250 Aspergillus species, Aspergillus fumigatus accounts for up to 80% of invasive human infections. A. fumigatus produces galactosaminogalactan (GAG), an exopolysaccharide composed of galactose and N-acetyl-galactosamine (GalNAc) that ...
Mark J Lee, Hong Liu, Bridget M Barker, Brendan D Snarr, Fabrice N Gravelat, Qusai Al Abdallah, Christina Gavino, Shane R Baistrocchi, Hanna Ostapska, Tianli Xiao, Benjamin Ralph, Norma V Solis, Mélanie Lehoux, Stefanie D Baptista, Arsa Thammahong, Robert P Cerone, Susan G W Kaminskyj, Marie-Christine Guiot, Jean-Paul Latgé, Thierry Fontaine, Donald C Vinh, Scott G Filler, Donald C Sheppard   +22 more
doaj   +1 more source

Characterizing the Pathogenic, Genomic, and Chemical Traits of Aspergillus fischeri, a Close Relative of the Major Human Fungal Pathogen Aspergillus fumigatus

Msphere, 2019
Aspergillus fumigatus is the primary cause of aspergillosis, a devastating ensemble of diseases associated with severe morbidity and mortality worldwide. A. fischeri is a close relative of A. fumigatus but is not generally observed to cause human disease.
Matthew E. Mead, Sonja L. Knowles, H. Raja, S. Beattie, Caitlin H. Kowalski, J. Steenwyk, L. P. Silva, Jéssica Chiaratto, L. Ries, G. Goldman, R. Cramer, N. Oberlies, A. Rokas   +12 more
semanticscholar   +1 more source

18‐FDG PET in the Evaluation of Therapeutic Response of Necrotizing Otitis Externa

The Laryngoscope, EarlyView.
PET performed well in assessing the therapeutic response of NEO, with excellent sensitivity but low specificity of visual analysis. A complementary quantitative analysis was useful to distinguish between satisfactory and insufficient partial responses. ABSTRACT Objective The duration of antibiotic treatment for necrotizing otitis externa (NEO) and the ...
Lucie Lécolier, Philippine Toulemonde, Damien Huglo, Clio Baillet, Pauline Thill, Gauthier Delaby   +5 more
wiley   +1 more source

High‐Throughput Gene Replacement in Aspergillus fumigatus

Current Protocols in Microbiology, 2019
Aspergillus fumigatus is a human pathogen and the principal etiologic agent of invasive and chronic aspergillosis leading to several hundreds of thousands of deaths every year. Very few antifungals are available to treat infections caused by A. fumigatus,
Can Zhao, M. Fraczek, L. Dineen, Ressa Lebedinec, J. Macheleidt, T. Heinekamp, D. Delneri, P. Bowyer, A. Brakhage, M. Bromley   +9 more
semanticscholar   +1 more source

Spectroscopic, X‐Ray Crystallographic, and Hirshfeld Surface Analyses for the Investigation of Intermolecular Interactions in Carboxamide Hydrazone Hybrids

ChemistryOpen, EarlyView.
Two novel carboxamide hydrazone hybrids are synthesized and characterized. Structural, spectroscopic, and computational analyses reveal dominant hydrogen bonding, π–π stacking, and reactive sites. Compound 2b exhibits potent antibacterial activity against Staphylococcus aureus, highlighting its potential as a cost‐effective therapeutic agent.
Nabila A. Kheder, Mostafa E. Salem, Saied M. Soliman, Ismail A. Elhaty, Naglaa S. Mahmoud, Mohamed Abdel‐Megid, Kamal M. Dawood   +6 more
wiley   +1 more source

Intermicrobial interaction: Aspergillus fumigatus siderophores protect against competition by Pseudomonas aeruginosa

PLoS ONE, 2019
Pseudomonas aeruginosa and Aspergillus fumigatus are pathogens frequently co-inhabiting immunocompromised patient airways, particularly in people with cystic fibrosis.
G. Sass, S. R. Ansari, Anna-Maria Dietl, Eric Déziel, H. Haas, D. Stevens   +5 more
semanticscholar   +1 more source