Gradient domain machine learning with composite kernels: improving the accuracy of PES and force fields for large molecules [PDF]
Mach. Learn.: Sci. Technol. 3 015005 (2022), 2021 The generalization accuracy of machine learning models of potential energy surfaces (PES) and force fields (FF) for large polyatomic molecules can be generally improved either by increasing the number of training points or by improving the models. In order to build accurate models based on expensive high-level ab initio calculations, much of recent ...
arxiv +1 more source
Aspirin and the Primary Prevention of Cardiovascular Diseases. An Approach Based on Individualized, Integrated Estimation of Risk [PDF]
, 2017 While the use of aspirin in the secondary prevention of cardiovascular (CVD) is well established, aspirin in primary prevention is not systematically recommended because the absolute CV event reduction is similar to the absolute excess in major bleedings.
Battistoni, Allegra +4 more
core +1 more source
Mechanistic view into the therapeutic effect, anticancer potential and the adverse effect of aspirin [PDF]
MATEC Web of ConferencesIn this research, the working mechanism behind the therapeutic effect of aspirin will be discussed in detail. Aspirin will also be assessed as a promising drug to treat cancerous cells in the future.
Ouyang Juan
doaj +1 more source
Nasal lysine aspirin challenge in the diagnosis of aspirin - exacerbated respiratory disease [PDF]
, 2013 Background Aspirin-exacerbated respiratory disease is under-diagnosed and therefore effective and inexpensive therapy with aspirin desensitization is rarely performed.
Darby, Y +6 more
core +1 more source
BMC Gastroenterology, 2020 Background Aspirin has been found to lower the occurrence rates of some cancers through the inhibition of the cyclooxygenase enzyme. For example, there is a well-known association between aspirin use and the occurrence of hepatocellular carcinoma (HCC ...
Yen-Hsiang Liao +8 more
doaj +1 more source
Lower mortality rate in elderly patients with community-onset pneumonia on treatment with aspirin [PDF]
, 2015 BACKGROUND: Pneumonia is complicated by high rate of mortality and cardiovascular events (CVEs). The potential benefit of aspirin, which lowers platelet aggregation by inhibition of thromboxane A2 production, is still unclear. The aim of the study was to
Barilla', Francesco +11 more
core +1 more source
Aspirin-dependent effects on purinergic P2Y1 receptor express [PDF]
, 2019 Chronic treatment with aspirin in healthy volunteers (HVs) is associated with recovery of adenosine diphosphate (ADP)-induced platelet activation. The purinergic P2Y1 receptor exerts its effects via a Gq-protein, which is the same biochemical pathway ...
Alemanno, Laura +8 more
core +1 more source
Identifying and reducing inappropriate aspirin use in primary care
BMJ Open Quality, 2023 Objective Recent studies have called into question the safety of aspirin use for the primary prevention of atherosclerotic cardiovascular disease, particularly in older adults.
Li Li +5 more
doaj +1 more source
Is clopidogrel better than aspirin following breakthrough strokes while on aspirin? A retrospective cohort study. [PDF]
, 2014 ObjectiveThere is insufficient evidence on which to base a recommendation for optimal antiplatelet therapy following a stroke while on aspirin. The objective was to compare clopidogrel initiation vs aspirin reinitiation for vascular risk reduction among ...
Chang, Ku-Chou +10 more
core +1 more source
Aspirin inhibits the acute venodilator response to furosemide in patients with chronic heart failure [PDF]
, 2001 OBJECTIVES: We sought to determine the effect of aspirin on the venodilator effect of furosemide in patients with chronic heart failure (CHF) BACKGROUND: Furosemide has an acute venodilator effect preceding its diuretic action, which is blocked
Andrew P Davie +33 more
core +1 more source