Results 141 to 150 of about 47,972 (292)

Вплив аспірину на загальні адаптаційні реакції та тимус в експерименті

, 2010
В эксперименте на крысах изучено влияние аспирина на массу тимуса, его морфометрию, гистологию и формирование общих неспецифических адаптационных реакций. Было выявлено уменьшение количества благоприятных типов реакций (спокойной и повышенной активации).
Радченко, О.М.
core  

Celecoxib in breast cancer prevention and therapy. [PDF]

, 2018
Breast cancer has a high incidence worldwide. The results of substantial studis reveal that inflammation plays an important role in the initiation, development, and aggressiveness of many malignancies. The use of celecoxib, a novel NSAID, is repetitively
Cao, Wei, Hao, Qiongyu, Li, Jieqing, Vadgama, Jaydutt V, Wu, Yong   +4 more
core  

Gastrula‐Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross‐Talk with TGF‐β Signaling Pathway

Advanced Science, EarlyView.
A gastrula‐premarked enhancer within the first intron of Cdx2 governs posterior embryonic development via both regulating Cdx2 expression in cis and coordinating TGF‐β signaling in trans to ensure proper posterior body development. Functional rescue in gastruloids reveals a Cdx2‐independent pathway, highlighting p‐Enh‐eRNA as key epigenetic ...
Yingying Chen, Fengxiang Tan, Qing Fang, Lin Zhang, Jiaoyang Liao, Penglei Shen, Yun Qian, Mingzhu Wen, Rui Song, Yonggao Fu, He Jax Xu, Ran Wang, Cheng Li, Zhen Shao, Jinsong Li, Naihe Jing, Xianfa Yang   +16 more
wiley   +1 more source

Is cardiopulmonary bypass a reason for aspirin resistance after coronary artery bypass grafting? [PDF]

, 2005
Nives Zimmermann, Mustafa Kurt, A. Wenk, Jordan M. Winter, E GAMS, T Hohlfeld   +5 more
openalex   +1 more source

Ligilactobacillus Murinus and Lactobacillus Johnsonii Suppress Macrophage Pyroptosis in Atherosclerosis through Butyrate‐GPR109A‐GSDMD Axis

Advanced Science, EarlyView.
Oral aspirin administration induces intestinal expansion of Lactobacillus murinus and Lactobacillus johnsonii, which suppresses the progression of atherosclerosis. This microbial expansion significantly enhances butyrate production by providing lactate as a metabolic substrate, thereby fostering the growth of butyrate‐producing bacteria. Butyrate plays
Rui Hua, Ning Ding, Yiming Hua, Xiaoke Wang, Yu Xu, Xiangrui Qiao, Xue Shi, Ting Bai, Ying Xiong, Xiaozhen Zhuo, Chong Fan, Juan Zhou, Yue Wu, Junhui Liu, Zuyi Yuan, Ting Li   +15 more
wiley   +1 more source

Emerging Nanotechnology Strategies for Obesity Therapy

Advanced Science, EarlyView.
Three types of nanomaterials used for obesity treatment are highlighted, including inorganic nanomaterials, organic nanomaterials and biomimetic nanomaterials. A detailed and comprehensive introduction to the recent nanotechnology strategies for obesity management is also provided, including drug delivery, photodynamic therapy, hyperthermia, gas ...
Weili Chang, Zhaoxu Meng, Yuezhu Zhao, Yake Qi, Zhou Li, He Lian   +5 more
wiley   +1 more source

Aspirin resistance candidate genes and their association with the risk of fatal cardiovascular events

Терапевтический архив, 2013
The review presents the current data available in the world literature on the most likely gene polymorphisms, such as cyclooxygenase, glycoproteins (GP) Ib/IIIa, GP Ibα, GP VI, adenosine diphosphate receptor P2Y1 and P2Y12 polymorphisms that may lead to ...
Iu I Grinshteĭn, A A Kosinova, I Iu Grinshteĭn   +2 more
doaj  

Endothelial injury and acquired aspirin resistance as promoters of regional thrombin formation and early vein graft failure after coronary artery bypass grafting [PDF]

, 2005
Robert Poston, Junyan Gu, James Brown, James S. Gammie, Charles S. White, Lei Nie, Richard N. Pierson, Bartley P. Griffith   +7 more
openalex   +1 more source

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

BInD: Bond and Interaction‐Generating Diffusion Model for Multi‐Objective Structure‐Based Drug Design

Advanced Science, EarlyView.
Can a generative model design molecules that truly understand their targets? BInD, a diffusion‐based framework, co‐generates 3D molecules and their interactions with proteins by learning target‐specific interacting patterns. With knowledge‐based guidance and NCI‐driven optimization, BInD balances affinity, geometry, and drug‐likeness – pushing the ...
Joongwon Lee, Wonho Zhung, Jisu Seo, Woo Youn Kim   +3 more
wiley   +1 more source