Results 151 to 160 of about 545 (197)
Performance evaluation of the waste activated sludge high‐rate (WASHR) process for septic wastewater treatment. Abstract The waste‐activated sludge high‐rate (WASHR) process is evaluated as a batch‐mode pre‐treatment for actual septage using a high‐rate contact stabilization (HRCS) approach.
Arman Shirali +2 more
wiley +1 more source
Abstract Engineering graduate students confuse the scientific method and problem solving when presenting their pre‐doctoral exams and theses: Science discourse adopts question and hypotheses to assert and establish a study's rationale, while it is problem and objectives in engineering design.
Gregory S. Patience +4 more
wiley +1 more source
Partial identification with categorical data and nonignorable missing outcomes
Abstract Nonignorable missing outcomes are common in real‐world datasets and often require strong parametric assumptions to achieve identification. These assumptions can be implausible or untestable, and so we may wish to forgo them in favour of partially identified models that narrow the set of a priori possible values to an identification region.
Daniel Daly‐Grafstein, Paul Gustafson
wiley +1 more source
Bayesian inverse ensemble forecasting for COVID‐19
Abstract Variations in strains of COVID‐19 have a significant impact on the rate of surges and on the accuracy of forecasts of the epidemic dynamics. The primary goal for this article is to quantify the effects of varying strains of COVID‐19 on ensemble forecasts of individual “surges.” By modelling the disease dynamics with an SIR model, we solve the ...
Kimberly Kroetch, Don Estep
wiley +1 more source
Exploring Healthcare Continuity in Pediatric‐Onset Multiple Sclerosis in the United States
ABSTRACT Objective Little is known about shifting from pediatric to adult‐focused multiple sclerosis (MS) care. This study aims to explore transition of care and follow‐up in the US pediatric‐onset MS (POMS) population. Methods Surveys were distributed to 10 sites in the US Network of Pediatric MS Centers (US NPMSC) about transition‐of‐care practices ...
Aaron W. Abrams +31 more
wiley +1 more source
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor +12 more
wiley +1 more source
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara +20 more
wiley +1 more source
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian +12 more
wiley +1 more source
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Pathophysiology of Haemostasis and Thrombosis, 2006
Describes the concept, mechanisms, adverse clinical events, and treatment of aspirin resistance as related to coronary arterial thrombosis.
Graeme J, Hankey, John W, Eikelboom
exaly +15 more sources
Describes the concept, mechanisms, adverse clinical events, and treatment of aspirin resistance as related to coronary arterial thrombosis.
Graeme J, Hankey, John W, Eikelboom
exaly +15 more sources
Mechanisms of aspirin resistance
Pharmacology & Therapeutics, 2014Aspirin is integral to the secondary prevention of cardiovascular disease and acts to impair the development of platelet-mediated atherothromboembolic events by irreversible inhibition of platelet cyclooxygenase-1 (COX-1). Inhibition of this enzyme prevents the synthesis of the potent pro-aggregatory prostanoid thromboxane A2.
Floyd, Christopher N., Ferro, Albert
openaire +5 more sources

