Results 141 to 150 of about 2,363,412 (175)
Lancet, The, 2006 Describes the concept, mechanisms, adverse clinical events, and treatment of aspirin resistance as related to coronary arterial thrombosis.
Graeme J. Hankey, John W. Eikelboom
exaly +12 more sources
Mechanisms of aspirin resistance
Pharmacology & Therapeutics, 2014 Aspirin is integral to the secondary prevention of cardiovascular disease and acts to impair the development of platelet-mediated atherothromboembolic events by irreversible inhibition of platelet cyclooxygenase-1 (COX-1). Inhibition of this enzyme prevents the synthesis of the potent pro-aggregatory prostanoid thromboxane A2.
Christopher N Floyd, Albert Ferro
exaly +5 more sources
Journal of Thrombosis and Haemostasis, 2005 Treatment failures occur with any drug and aspirin is no exception. Evidence is growing to indicate that there are subpopulations that do not respond to antithrombotic action of aspirin. The term 'aspirin resistance' has been used to describe a number of different phenomena, including inability of aspirin to: (i) protect against cardiovascular events ...
Marek Sanak, A Szczeklik
exaly +6 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Thrombosis Research, 2007
Aspirin resistance refers to less than expected suppression of thromboxane A(2) production by aspirin and has been reported to be independently associated with an increased risk of adverse cardiovascular events. Possible causes of aspirin resistance include poor compliance, drug interaction, inadequate aspirin dose, increase turnover of platelets ...
Huyen A, Tran +3 more
openaire +4 more sources
Aspirin resistance refers to less than expected suppression of thromboxane A(2) production by aspirin and has been reported to be independently associated with an increased risk of adverse cardiovascular events. Possible causes of aspirin resistance include poor compliance, drug interaction, inadequate aspirin dose, increase turnover of platelets ...
Huyen A, Tran +3 more
openaire +4 more sources
Lack of aspirin effect: aspirin resistance or resistance to taking aspirin?
American Heart Journal, 2004A lack of aspirin effect on platelets after a myocardial infarction (MI) is associated with poor health outcome. This lack of effect may be due to biological resistance to aspirin or due to nonadherence (the patient is not taking the aspirin, hence it has no effect).
Gad, Cotter +9 more
openaire +2 more sources
Current Atherosclerosis Reports, 2009
Aspirin resistance (AR) still lacks a universally accepted definition, but it may be discussed as either a laboratory phenomenon or a clinical presentation. Laboratory resistance is mainly defined as abnormal platelet response to aspirin, whereas the clinical manifestation is the failure of aspirin to prevent cardiovascular events.
Gilead I, Lancaster +2 more
openaire +2 more sources
Aspirin resistance (AR) still lacks a universally accepted definition, but it may be discussed as either a laboratory phenomenon or a clinical presentation. Laboratory resistance is mainly defined as abnormal platelet response to aspirin, whereas the clinical manifestation is the failure of aspirin to prevent cardiovascular events.
Gilead I, Lancaster +2 more
openaire +2 more sources
Future Cardiology, 2005
“The clinical impact of aspirin resistance with cardiovascular events is now becoming evident, with aspirin nonresponders having nearly a threefold increased risk of cardiovascular death” Aspirin resistance is an increasingly recognized phenomenon denoting a diminished platelet inhibitory effect of aspirin.
Sasidhar, Guthikonda, Neal S, Kleiman
openaire +2 more sources
“The clinical impact of aspirin resistance with cardiovascular events is now becoming evident, with aspirin nonresponders having nearly a threefold increased risk of cardiovascular death” Aspirin resistance is an increasingly recognized phenomenon denoting a diminished platelet inhibitory effect of aspirin.
Sasidhar, Guthikonda, Neal S, Kleiman
openaire +2 more sources
Aspirin and Clopidogrel Resistance
Hematology, 2007AbstractAspirin and clopidogrel provide significant clinical benefit in patients with cardiovascular disease. However, given the complexity of platelet activation, it is not surprising that aspirin or clopidogrel prevent a small proportion of cardiovascular events.
Desmond J, Fitzgerald, Andrew, Maree
openaire +2 more sources
Aspirin resistance in atherosclerosis
Current Atherosclerosis Reports, 2008Clinically, aspirin resistance is defined as the failure of aspirin therapy to prevent an acute vascular thrombotic event despite regular intake of appropriate doses. In the laboratory, aspirin resistance encompasses the drug's failure to attain a particular level of platelet inhibition. From a clinical standpoint, the inability of aspirin to prevent a
Price, Blair, Jane E, Freedman
openaire +2 more sources
Aspirin resistance and other aspirin-related concerns
Neurological Sciences, 2015Aspirin is a widely used medication and has become a cornerstone for treating cardiovascular disease. Aspirin can significantly reduce the incidence of cardiovascular ischemic events, recurrence and mortality, thereby improving the long-term prognosis of patients.
Gaoyu, Cai +5 more
openaire +2 more sources