Results 61 to 70 of about 5,957 (204)

Vaccinations in Pediatric Hematology and Oncology: Biologic Basis, Clinical Applications, and Perspectives

Vaccines
Children with hemato-oncological diseases represent a heterogeneous population at heightened risk for vaccine-preventable diseases. Their immunosuppressed state reduces vaccine efficacy and raises safety concerns regarding live attenuated vaccines due to
Baldassarre Martire, Alessandra Beni, Maria Felicia Mastrototaro, Veronica Santilli, Giorgio Ottaviano, Davide Montin, Caterina Rizzo, Mayla Sgrulletti, Michele Miraglia del Giudice, Giorgio Costagliola, Viviana Moschese   +10 more
doaj   +1 more source

Integrating Chain‐of‐Thought and Retrieval Augmented Generation Enhances Rare Disease Diagnosis From Clinical Notes

Medicine Bulletin, Volume 2, Issue 2, Page 167-183, March 2026.
ABSTRACT Background Several studies show that large language models (LLMs) struggle with phenotype‐driven gene prioritization for rare diseases. These studies typically use Human Phenotype Ontology (HPO) terms to prompt foundation models such as GPT and LLaMA to predict candidate genes.
Zhanliang Wang, Da Wu, Quan Nguyen, Kai Wang   +3 more
wiley   +1 more source

European Society for the Study of Coeliac Disease (ESsCD) 2025 Updated Guidelines on the Diagnosis and Management of Coeliac Disease in Adults. Part 2: Management, Follow‐Up, and Complex Disease Courses

United European Gastroenterology Journal, Volume 14, Issue 2, March 2026.
ABSTRACT Introduction Since the publication of the first European Society for the Study of Coeliac Disease (ESsCD) guidelines in 2019, substantial advances have been made in understanding the management and complex disease courses of coeliac disease (CeD) in adults.
Abdulbaqi Al‐Toma, Federica Branchi, Fabiana Zingone, Annalisa Schiepatti, Georgia Malamut, Cristina Canova, Isabella Rosato, Honoria Ocagli, Nick Trott, Luca Elli, Alina Popp, Carmen Gianfrani, Renata Auricchio, Andra Neefjes‐Borst, David S. Sanders, Christophe Cellier, Chris J. Mulder, Gerd Bouma, Knut E. A. Lundin, Ludvig M. Sollid, Michael Schumann   +20 more
wiley   +1 more source

Fever and asplenia: a dangerous association [PDF]

BMJ Case Reports, 2017
A 77-year-old splenectomised woman presented with temperatures reaching 38.5°C in the last 24 hours. The clinical presentation was non-specific and blood tests came back normal: a diagnosis of acute gastroenteritis was made. The patient’s clinical state then deteriorated rapidly; she developed septic shock, acute renal failure, disseminated ...
Halil Yildiz, Jean Cyr Yombi
openaire   +3 more sources

Incidence of RSV‐ and Influenza‐Associated Hospitalizations With Community‐Acquired Pneumonia and Other Acute Respiratory Infection Among Adults in Japan in 2022–2024: APSG‐J2 Study

Influenza and Other Respiratory Viruses, Volume 20, Issue 3, March 2026.
ABSTRACT Background Quantifying the burden of respiratory syncytial virus (RSV) in adults is challenging compared to influenza, and data among older adults remain scarce in Japan. Country‐specific evidence is essential to support RSV vaccination policy.
Haruka Maeda, Shingo Masuda, Bhim Gopal Dhoubhadel, Yuka Fujita, Yuji Akiba, Yutaka Nishigaki, Kei Nakashima, Hiroyuki Ito, Masayuki Nogi, Yoshihito Otsuka, Masayuki Ishida, Eiji Takeuchi, Norichika Asoh, Toyomitsu Sawai, Koichi Hayakawa, Eileen M. Dunne, Claudia Schwarz, Bradford D. Gessner, Elizabeth Begier, Shuhei Ito, Ataru Igarashi, Shinobu Osanai, Konosuke Morimoto, Koya Ariyoshi, Adult Pneumonia Study Group‐Japan 2 (APSG‐J2)   +24 more
wiley   +1 more source

Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia [PDF]

, 2013
Isolated congenital asplenia (ICA) is characterized by the absence of a spleen at birth in individuals with no other developmental defects. The patients are prone to life-threatening bacterial infections.
Baretto, Richard, Stephan, J-L, Abhyankar, A., Itan, Y., Casanova, J.L., Pollard, Andrew J, Bolze, A, Patin, Etienne, Williams, A.P., Duddridge, Michael, Puel, A, Conley, Mary Ellen, Emile, JF, Orbach, Daniel, Sackstein, Paul, Quintana-Murci, Lluis, Plebani, Alessandro, Emile, Jean-Francois, Hammarstrom, L, Gaud, Catherine, Faust, S.N., Orbach, D, Pollard, AJ, Stephan, J.L., Casanova, JL, Mahlaoui, Nizar, Selleri, Licia, Abhyankar, Avinash, Abhyankar, A, Casanova, J-L, Sorensen, R., Emile, J.F., Conley, ME, Bolze, Alexandre, Sorensen, Ricardo, Hammarstrom, Lennart, Turner, B, Gaud, C, Williams, AP, Sackstein, P., Duddridge, M., Trede, N, Kini, Usha, Brebner, S., Baretto, R., Byun, M, Frange, Pierre, Mahlaoui, N., Plebani, A, Picard, Capucine, Stephan, JL, Ellis, S.R., Frange, P, Trede, N., Conley, M.E., Itan, Y, Mahlaoui, N, Orbach, D., Turner, Bridget, Faust, Saul N, Pickard, c., Quintana-Murci, L., Trede, Nikolaus, Gaud, C., Hammarstrom, L., Ellis, Steven R, Bolze, A., Patin, E., Emile, J-F, Selleri, L., Pollard, Andrew, Frange, P., Abel, L, Sackstein, P, Picard, C, Itan, Yuval, Abel, L., Kini, U., Selleri, L, Kini, U, Stephan, Jean-Louis, Sorensen, R, Faust, SN, Baretto, R, Ellis, SR, Brebner, S, Duddridge, M, Byun, M., Turner, B., Puel, Anne, Williams, Anthony P, Patin, E, Quintana-Murci, L, Pollard, A.J., Plebani, A., Abel, Laurent, Casanova, Jean-Laurent, Brebner, Samuel, Puel, A., Byun, Minji   +99 more
core   +2 more sources

Laparoscopic Partial Splenectomy for a Giant Congenital Splenic Cyst in a Child: Case Report and Focused Literature Review

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT An 11‐year‐old boy with a 16 × 14.5 cm congenital splenic cyst underwent laparoscopic upper‐pole partial splenectomy after negative hydatid workup and vaccination. Recovery was uneventful; histology confirmed epithelial cyst. Spleen‐preserving surgery provided durable symptom relief and preserved function.
Ahmed Alanzi, Dawood Alatefi, Malik Alkabazi, Bano Alsaleh, Khaled M. AlAani, Samah Hakmi   +5 more
wiley   +1 more source

Case Report: A “senior” with serpentine-like syndrome—treatment of combined brachyoesophagus, intrathoracic stomach and cervical rachischisis

Frontiers in Pediatrics
Serpentine-like syndrome, characterized by the combination of intrathoracic stomach, a notably short esophagus anomaly, splenic abnormalities, and cervical spine malformations, has been associated with a high mortality rate since its identification in ...
Judith Lohmann, Anna Freund, Tobias Klein, Daniel Acero, Thomas Boemers   +4 more
doaj   +1 more source

Natural‐History Mapping of Lysosomal Storage Disorders (LSDs): Gaucher Disease as a Model for Precision Care

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Natural‐history datasets have become pivotal for drug development and for shaping clinical‐practice guidelines in rare diseases, yet many lysosomal storage disorders would benefit from deep phenotyping and modern analytic methods. Our objective was to integrate the past decade of genomic, cellular, treatment‐outcome, and regulatory advances ...
Noor Ul Ain, Maya Vaishnaw, Pramod. K. Mistry   +2 more
wiley   +1 more source

Malaria Screening and Treatment in Hematopoietic Cell Transplant Donors and Sickle Cell Disease Candidates/Recipients: A Case Series Using Malaria Polymerase Chain Reaction Testing and a Literature Review

Transplant Infectious Disease, Volume 28, Issue 1, January/February 2026.
Malaria polymerase chain reaction (PCR) testing is more sensitive than conventional diagnostics. Routine PCR screening of at‐risk asymptomatic hematopoietic cell donors and transplant candidates may prevent unnecessary deferrals or treatment. In our experience, PCR negativity during screening or after treatment supports donor/candidate eligibility ...
Mary M. Czech, Sanchita Das, Emily Limerick, Courtney Fitzhugh, Matthew Hsieh, Jennifer Cuellar‐Rodriguez   +5 more
wiley   +1 more source