Results 61 to 70 of about 4,209,255 (350)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
The Journal of Law, Economics, and Organization, 2019 Abstract This article explores the problem of assembling capital for projects. It can be difficult to assemble capital, when it is disaggregated, for a project that exhibits increasing returns. Small investors may be reluctant to participate, as they may question the ability of the project owner to raise the additional capital he ...
Akerlof, Robert J., Holden, Richard
openaire +2 more sources
The Resolution of the World Health Assembly on the Elimination of Avoidable Blindness
Community Eye Health Journal, 2003 WHA 56.26. Agenda Item 14.17: 28 May 2003.
Fifty-sixth World Health Assembly
doaj
Investigation of Parameters of Fused Deposition Modelling 3D Prints with Compression Properties
Advances in Materials Science and Engineering, 2022 Three-dimensional (3D) printing has been attracting a great deal of attention in recent years in many application fields, for example, in the aerospace, construction, industry, art, education, protection, security, and medical fields.
Dereje Berihun Sitotaw +3 more
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Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
, 2020 We introduce and analyze the concept of an assembly map from the original homotopy theoretic point of view. We give also interpretations in terms of surgery theory, controlled topology and index theory. The motivation is that prominent conjectures of Farrell-Jones and Baum-Connes about K- and L-theory of group rings and group C^*-algebras predict that ...
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Brain macrophages and pial fibroblasts promote inflammation in a hypomyelination model
Acta Neuropathologica CommunicationsMany neurological diseases remain difficult to treat, necessitating further elucidation of their pathogenesis. Conditional inactivation of Pdgfra in Nestin-expressing cells leads to the depletion of platelet-derived growth factor receptor-alpha+ (PDGFRα+)
Noriko Okuno +12 more
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Shaft seal assembly for high speed and high pressure applications [PDF]
, 1979 A seal assembly is provided for reducing the escape of fluids from between a housing and a shaft rotably mounted in the housing. The seal assembly comprises a pair of seal rings resiliently connected to each other and disposed in side-by-side ...
Hadt, W. F., Ludwig, L. P.
core +1 more source