Results 81 to 90 of about 1,175,139 (268)
Mechanical Engineering JournalThe 7000 series aluminum alloys are high-strength materials widely utilized for weight reduction in transportation equipment and aerospace applications.
Tatsuya FUNAZUKA +4 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
An End-to-End Computationally Lightweight Vision-Based Grasping System for Grocery Items
SensorsVision-based grasping for mobile manipulators poses significant challenges in machine perception, computational efficiency, and real-world deployment. This study presents a computationally lightweight, end-to-end grasp detection framework that integrates
Thanavin Mansakul +5 more
doaj +1 more source
, 2020 We introduce and analyze the concept of an assembly map from the original homotopy theoretic point of view. We give also interpretations in terms of surgery theory, controlled topology and index theory. The motivation is that prominent conjectures of Farrell-Jones and Baum-Connes about K- and L-theory of group rings and group C^*-algebras predict that ...
openaire +2 more sources
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Communications in Development and Assembling of Textile ProductsUltrasonic welding is an efficient method of joining thermoplastic fabrics or other textile semi-finished products in a watertight manner. It is applied in the making of functional clothing, such as chemical protective clothing, sportswear or smart ...
Alexander Reich +2 more
doaj +3 more sources
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source