Results 81 to 90 of about 2,004,232 (316)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

Effect of tumour necrotic factor‐α, interleukin‐17 and interleukin‐22 on the expression of filaggerin‐2 and hornerin: Analysis of a three‐dimensional psoriatic skin model

open access: yesSkin Health and Disease
Background Filaggrin‐2 (FLG2) and hornerin (HRNR) are members of the S100 fused‐type protein family, which share many properties with filaggrin (FLG). A previous study demonstrated that the expression of FLG2 was significantly decreased in psoriatic skin
Teruhiko Makino   +4 more
doaj   +1 more source

General Assembly open meetings law

open access: yes, 2004
Title from caption of PDF document (viewed Jan. 26, 2006).; "This ... Brief is an update of an earlier Brief on this subject dated November 8, 2002 (Volume 124 Issue 11)."; "October 4, 2004."; Harvested from the web on 1/27/06This brief explains how ...
Goshay, Pamela.
core  

Decision on the Hissene Habre Case Doc. Assembly/Au/11(Xv) [PDF]

open access: yes, 2010
Progress Report of the Commission on the Implementation of Decision Assembly/AU/ Dec.240 ...
The Assembly
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Decision on the Pan African University Statutes Doc. Assembly/Au/11(Xx) [PDF]

open access: yes, 2012
Decision, Assembly/AU/Dec.290(XV) adopted in Kampala, Uganda, in July 2010 to create the Pan African University ...
The Assembly
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Risk Evaluation of the NCD Risk Calculator for Open Pancreaticoduodenectomy in Elderly Patients: A Validation Study

open access: yesAnnals of Gastroenterological Surgery
Background There is no clear indication for surgery in pancreaticoduodenectomy (PD) for the elderly patients. The aim of this study was to use real‐world data to investigate the usefulness of preoperative risk assessment with the risk calculator ...
Nana Kimura   +9 more
doaj   +1 more source

Decision on the Progress Report of the Chairperson of the Commission on the Implementation Of Decision Assembly/Au/Dec.275(Xiv) On The Year Of Peace And Security In Africa Doc. Assembly/Au/7(Xv) [PDF]

open access: yes, 2010
Report of the Chairperson of the Commission on the implementation of Decision Assembly/AU/Dec.275(XIV) on the Year of Peace and Security in Africa adopted by the Fourteenth Ordinary Session of the Assembly in Addis Ababa, Ethiopia in February ...
The Assembly
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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