Results 71 to 80 of about 2,010,216 (316)

Decision on the Implementation of the Assembly Decisions on the International Criminal Court Doc. Ex.Cl/670(Xix) [PDF]

open access: yes, 2010
Progress Report of the Commission on the Implementation of Decision Assembly/AU/Dec.296 (XV) adopted by the Fifteenth Ordinary Session of the Assembly in Kampala, Uganda on 31 July ...
The Assembly
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Decision on the Transformation of the African Union Commission into the African Union Authority Doc. Assembly/Au/9(Xvii) [PDF]

open access: yes, 2009
Progress Report of the Commission on the Implementation of Assembly Decision Assembly/AU/ Dec.341(XVI) on the Transformation of the African Union Commission into the African Union ...
The Assembly
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Decision on the Hissene Habre Case Doc. Assembly/Au/11(Xv) [PDF]

open access: yes, 2010
Progress Report of the Commission on the Implementation of Decision Assembly/AU/ Dec.240 ...
The Assembly
core  

Effect of tumour necrotic factor‐α, interleukin‐17 and interleukin‐22 on the expression of filaggerin‐2 and hornerin: Analysis of a three‐dimensional psoriatic skin model

open access: yesSkin Health and Disease
Background Filaggrin‐2 (FLG2) and hornerin (HRNR) are members of the S100 fused‐type protein family, which share many properties with filaggrin (FLG). A previous study demonstrated that the expression of FLG2 was significantly decreased in psoriatic skin
Teruhiko Makino   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Decision on the Pan African University Statutes Doc. Assembly/Au/11(Xx) [PDF]

open access: yes, 2012
Decision, Assembly/AU/Dec.290(XV) adopted in Kampala, Uganda, in July 2010 to create the Pan African University ...
The Assembly
core  

Risk Evaluation of the NCD Risk Calculator for Open Pancreaticoduodenectomy in Elderly Patients: A Validation Study

open access: yesAnnals of Gastroenterological Surgery
Background There is no clear indication for surgery in pancreaticoduodenectomy (PD) for the elderly patients. The aim of this study was to use real‐world data to investigate the usefulness of preoperative risk assessment with the risk calculator ...
Nana Kimura   +9 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

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