Results 71 to 80 of about 3,944,654 (298)
Brain macrophages and pial fibroblasts promote inflammation in a hypomyelination model
Acta Neuropathologica CommunicationsMany neurological diseases remain difficult to treat, necessitating further elucidation of their pathogenesis. Conditional inactivation of Pdgfra in Nestin-expressing cells leads to the depletion of platelet-derived growth factor receptor-alpha+ (PDGFRα+)
Noriko Okuno +12 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Variable length strut with longitudinal compliance and locking capability [PDF]
, 1985 A variable length strut device is illustrated for connecting two associated structures which includes an outer load bearing shell, a drive assembly, a length varying compliance assembly positioned by drive assembly, and a strut rod locking assembly.
Belew, R. R.
core +1 more source
, 2012 A computational investigation was carried out to understand the aggregation of nanoscale graphene with two typical assembly pathways of stacking assembly and sliding assembly in water.
Lv, Wenping, Wu, Renan
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
ThurGood: Evaluating Assembly-to-Assembly Mapping [PDF]
Journal of Computational Biology, 2004 The alignment and mapping of large genomic sequences is the focus of much recent research. However, relatively little has been done so far about testing and validating alignment methods. We introduce criteria and new tools we have developed for alignment evaluation. These tools have already proved useful in the evaluation and ranking of several methods
Hagit, Shatkay +5 more
openaire +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Annals of Gastroenterological SurgeryIntroduction The prognosis of pancreatic ductal adenocarcinoma (PDAC) in patients with positive peritoneal washing cytology (CY1) is poor. We aimed to evaluate the results of staging laparoscopy (SL) and treatment efficacy in CY1 patients based on a ...
Takamichi Igarashi +9 more
doaj +1 more source
Carriage-rail assembly for high-resolution mechanical positioning [PDF]
, 1970 Carriage-rail assembly effects extreme resolution and position accuracy with little friction, and is applicable to such apparatus as optical benches, inspection fixtures, machine tools, and photographic equipment. Directions for assembly construction are
Bosworth, R. H., Roney, B. W.
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source