Results 71 to 80 of about 131,326 (303)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

An integrated representation scheme for assembly sequence planning and assembly line balancing [PDF]

, 2011
In a typical assembly optimisation, Assembly Sequence Planning and Assembly Line Balancing are performed independently. However, competition has compelled the manufacturer to innovate by integrating the optimisation of both problems. To incorporate ASP
Tiwari, Ashutosh, Hutabarat, Windo, Ab Rashid, Mohd Fadzil Faisae   +2 more
core  

Hamiltonian polygonal path in assembly graph of FTTM [PDF]

, 2019
Fuzzy Topographic Topological Mapping (FTTM) consists of four topological spaces that are homeomorphic to each other. A sequence of FTTMn is a combination of n terms of FTTM. An assembly graph is a graph with all vertices have valency of one or four.
Tahir Ahmad, Abd. Shukor, N., Zainab Mahamud, Idris, A., Mahamud, Z., Ahmad, T., Amidora Idris, Noorsufia Abd Shukor   +7 more
core   +1 more source

The Construction of Knowledge Graphs in the Assembly Domain Based on Deep Learning

IEEE Access
The operation scenario of human-robot collaboration assembly involves multiple channels to acquire assembly domain knowledge data. In order to equip collaborative robots with certain general knowledge of assembly work and logical reasoning ability, this ...
Jing Qu, Yanmei Li, Huilong Du, Wen Wang, Weiping Fu   +4 more
doaj   +1 more source

De Novo Assembly Methods for Next Generation Sequencing Data

Tsinghua Science and Technology, 2013
The recent breakthroughs in next-generation sequencing technologies, such as those of Roche 454, Illumina/Solexa, and ABI SOLID, have dramatically reduced the cost of producing short reads of the genome of new species.
Yiming He, Zhen Zhang, Xiaoqing Peng, Fangxiang Wu, Jianxin Wang   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Shotgun assembly of random graphs

Probability Theory and Related Fields
Abstract In the graph shotgun assembly problem, we are given the balls of radius r around each vertex of a graph and asked to reconstruct the graph. We study the shotgun assembly of the Erdős-Rényi random graph $${\mathcal {G}}(n,p)$$ G
Tom Johnston, Gal Kronenberg, Alexander Roberts, Alex Scott 0001   +3 more
openaire   +2 more sources

Digital assembly planning using graph-based design languages [PDF]

, 2023
This paper illustrates a new engineering approach in the field of digital production planning using graph-based design languages. After introducing the overall process of graph-based production engineering, this contribution presents its most important ...
Stetter, Ralf, Manns, Martin, Breckle, Theresa, Kiefer, Jens   +3 more
core   +1 more source

HaVec: An Efficient de Bruijn Graph Construction Algorithm for Genome Assembly

International Journal of Genomics, 2017
Background. The rapid advancement of sequencing technologies has made it possible to regularly produce millions of high-quality reads from the DNA samples in the sequencing laboratories. To this end, the de Bruijn graph is a popular data structure in the
Md Mahfuzer Rahman, Ratul Sharker, Sajib Biswas, M. Sohel Rahman   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source