Results 91 to 100 of about 3,816,397 (298)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Assessing the knowledge index of the region
Вестник Российского экономического университета имени Г. В. Плеханова, 2019 Economy of knowledge is an economic formation, where today’s generation of young people will work. It is quite good that many scientists try to forecast what it will be like.
S. N. Kukushkin
doaj +1 more source
Sustainability Impact Assessment of World Trade Negotiations: Current Practice and Lessons for Further Development [PDF]
Sustainability Impact Assessment (SIA) is an increasingly accepted form of strategic impact assessment, and has recently been adopted, for example, as the preferred method of ex ante policy assessment in the European Community.
George, Clive, Kirkpatrick, Colin
core +1 more source
A reliability based consistent fuzzy preference relations for risk assessment in oil and gas industry [PDF]
, 2019 In decision making, linguistic variables tend to be complex to handle but they make more sense than classical fuzzy numbers. Fuzziness is not sufficient enough to deal with information and degree of reliability of information is critical.
Abu Bakar, Ahmad Syafadhli +4 more
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Carbon Footprint of a Typical Crop–Livestock Dairy Farm in Northeast China
AgricultureDairy farming is one of the most important sources of greenhouse gas (GHG) emissions in the livestock sector. In order to identify the key emission links and the best emission-reduction strategies for combined dairy farms, this study selected a typical ...
Yurong Wang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Methodology note on the data collection and impact analysis of the implementation of the pilots.
+12 more sources