Results 91 to 100 of about 150,528 (281)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
, 2014 Many Christian tertiary educators share a passion to see holistic transformation in students’ lives. This qualitative study grew out of the desire to explore whether students who are not Christ-followers, but who apply to study within an overtly ...
Smith, Ruth
core
Catching them is one thing, keeping them is something else: reflections on teaching first year university students [PDF]
, 2009 [Abstract]: This paper documents teaching practices that have been identified, by the teaching team, as improving student success rates in a first year tertiary level compulsory subject.
Lynch, Bernadette +2 more
core
Beginning Mathematical Writing Assignments
Prompt, 2019 Writing assignments in any mathematics course always present several challenges, particularly in lower-level classes where the students are not expecting to write more than a few words at a time.
Alexander Halperin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Analyze a Published Research Study: An Assignment to Scaffold Reading Challenging Academic Texts
Prompt, 2019 "Analyze a Published Research Study" invites students to examine a published study's research methods to learn not only what a research report says, but also how the research was designed, carried out, and communicated.
R. Mark Hall
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Scaffolded Daily Writing Assignments Introducing the Writing of Mathematical Proofs
Prompt, 2019 Writing mathematical proofs is a key component of writing in the discipline in mathematics. Historically, many students have struggled in pursuing this endeavor, particularly during their early exposure to the process.
David Abrahamson
doaj +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source