Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Web-based writing support: making it useable for distance teachers [PDF]
, 2012 This paper considers the issues that distance teachers in higher education who are not writing specialists face in supporting their students’ academic writing development. We discuss the usefulness of open web-based writing support resources, and propose
Goodfellow, Robin +2 more
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Self-Assessment in Learning: The Relationship Between Active Feedback Strategies And Metacognitive Development [PDF]
, 2014 The aim of this action research study was to test the hypothesis that students who take an active part in the feedback process will increase their metacognitive development and raise their achievement.
Thirtle, Sarah
core +2 more sources
A Poster Assignment Connects Information Literacy and Writing Skills.
Issues in Science and Technology Librarianship, 2015 This paper describes the implementation of a poster assignment in a writing and information literacy course required for undergraduate Life Sciences and Environmental Biology majors with the Faculty of Agricultural and Environmental Sciences at McGill ...
Natalie Waters
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Reflections on a degree initiative: the UK's Birmingham Royal Ballet dancers enter the University of Birmingham [PDF]
, 2003 This paper provides an opportunity to share experiences and perceptions of the first 5 years of a degree programme for professional dancers. A partnership developed in the mid-1990s between the UK's Birmingham Royal Ballet and the University of ...
BANNERMAN C. +20 more
core +1 more source
Students' intrinsic motivation in EFL academic writing: Topic-based interest in focus
HeliyonWriting as a productive skill is extremely challenging for EFL students. To promote their writing effectiveness, students' intrinsic motivation must be enhanced by allowing them to self-assign writing topics or write about topics of interest.
Ali Abbas Falah Alzubi, Mohd Nazim
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Boston University Wind Ensemble, December 11, 2003 [PDF]
, 2003 This is the concert program of the Boston University Wind Ensemble performance on Thursday, December 11, 2003 at 8:00 p.m., at the Tsai Performance Center, 685 Commonwealth Avenue, Boston, Massachusetts.
School of Music, Boston University
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Bridging Rhetorical Genre Studies and Ethics of Representation in Meeting Minutes
Prompt, 2019 This essay describes a project that introduces undergraduate students in a technical and professional writing course to rhetorical genre studies, context, and ethics.
Kelly Whitney
doaj +1 more source