Results 91 to 100 of about 2,089,947 (275)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Processes for understanding sustainability as a goal and practice
Journal of Geography, Politics and Society, 2017 The concept of sustainability has become one of today’s most widely used and controversial concepts. It is therefore important to develop activities within organizational context in order to increase co-workers understanding of the goals for more ...
Anette Oxenswärdh
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Complex Mixture Analysis of Organic Compounds in Yogurt by NMR Spectroscopy
Metabolites, 2016 NMR measurements do not require separation and chemical modification of samples and therefore rapidly and directly provide non-targeted information on chemical components in complex mixtures.
Yi Lu +3 more
doaj +1 more source
Consistency and Monotonicity in One-Sided Assignment Problems [PDF]
One-sided assignment problems combine important features of two well-known matching models. First, as in roommate problems, any two agents can be matched and second, as in two-sided assignment problems, the payoffs of a matching can be divided between ...
Alexandru Nichifor +1 more
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Flipped Classroom Activity Using the PTA Model in an Introductory Sociology Course
Prompt, 2018 This scaffolded writing-to-learn activity incorporates a number of Writing Across the Curriculum-based suggestions that draw upon the strengths of student reflection, the PTA (prioritization, translation, and analogization) model of concentric thinking ...
Lauren M. Sardi
doaj +1 more source
The maximun and the addition of assigment games [PDF]
In the framework of two-sided assignment markets, we first consider that among several markets, the players may choose where to trade. It is shown that the corresponding game, represented by the maximum of a finite set of assignment games, may not be ...
Marina Nunez, Silvia Miquel
core +1 more source