Results 71 to 80 of about 2,109,388 (295)
THE IMPLEMENTATION OF GRAMMATICAL FUNCTIONS IN FUNCTIONAL DISCOURSE GRAMMAR [PDF]
, 2007 underlying representation in a more or less across the board fashion, only taking into consideration the language dependent semantic function hierarchy.
Bakker, Dik, Siewierska, Anna
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Applied SciencesSolid-state nuclear magnetic resonance (ssNMR) spectroscopy enables studying complex macromolecules with low solubility. Compared to solution NMR, few tools exist for biomacromolecule ssNMR data analysis.
Andrea Estefania Lopez Giraldo +2 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Spectral Analyses and Structural Elucidation of Azilsartan
Chinese Journal of Magnetic Resonance, 2019 Azilsartan is a novel AT-1 angiotensin Ⅱ receptor blocker, which reduces blood pressure mildly without the side effect of cough. The drug is believed to have a large market potential. In this study, the drug was analyzed by ultraviolet spectroscopy (UV),
WANG Ya-lan +2 more
doaj +1 more source
The referee assignment problem [PDF]
, 2019 In collaboration between a UPC spinoff, Barcelogic, and the Dutch Football Federation (KNVB), we define, study, implement and evaluate different approaches for solving the so-called Referee Assignment Problem(RAP).
Vallespi Soro, Farners
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Frontiers in Ecology and Evolution, 2019 The measurement of naturally occurring stable hydrogen (δ2H) and carbon (δ13C) isotopes in wings of the eastern North American monarch butterflies (Danaus plexippus) have proven useful to infer natal origins of individuals overwintering in Mexico.
Keith A. Hobson +3 more
doaj +1 more source
Probabilistic Argumentation with Epistemic Extensions and Incomplete Information [PDF]
, 2014 argumentation offers an appealing way of representing and evaluating arguments and counterarguments. This approach can be enhanced by a probability assignment to each argument. There are various interpretations that can be ascribed to this assignment. In
Hunter, Anthony, Thimm, Matthias
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