Results 61 to 70 of about 69,701 (316)

Transcriptional insights on the incomplete cytoplasmic maturation and developmental potential of oocytes cultured without granulosa cells in mice

BMC Genomics
Background Oocyte maturation is crucial for female fertility and embryonic development, encompassing nuclear and cytoplasmic maturation. Supportive cells of follicles, such as granulosa cells, are essential for oocyte growth and maturation.
Yibo Wang, Yichuan Zhang, Tianjie Li, Yun Ren, Ping Zhou, Lin Fu, Chenxi Xiao, Ziying Huang, Hanji Huang, Wenfeng Xie, Yuxin Luo, Yanan Qi, Hongcui Zhao, Yang Yu, Yong Fan, Heng Pan   +15 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Efficacy and safety of mesenchymal stem cell therapy for ovarian ageing in a mouse model

Stem Cell Research & Therapy
Background Ovarian ageing is one of the major issues that impacts female fertility. Mesenchymal stem cell (MSC)-based therapy has made impressive progress in recent years.
Wendi Pei, Lin Fu, Wenhuan Guo, Yibo Wang, Yong Fan, Rui Yang, Rong Li, Jie Qiao, Yang Yu   +8 more
doaj   +1 more source

Assisted reproductive technology in Europe 2007 : results generated from European registers by ESHRE [PDF]

, 2012
Peer ...
Nygren, K G, Bhattacharya, Siladitya, Korsak, V, Bhattacharya, S, de Mouzon, J, Andersen, Anders Nyboe, Castilla, J A, Andersen, A Nyboe, Ferraretti, AP, Nyboe Andersen, A, Ferraretti, A P, Castilla, JA, Nygren, KG, Goossens, V, Kupka, M   +14 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Growth Hormone Promotes in vitro Maturation of Human Oocytes

Frontiers in Endocrinology, 2019
Increasing the success rate of in vitro maturation (IVM) for human oocytes has a major clinical significance. Previous studies have shown that growth hormone (GH) added into IVM medium could promote IVM of oocytes from non-human beings.
Yue Li, Yue Li, Yue Li, Hui Liu, Hui Liu, Hui Liu, Qingqing Yu, Qingqing Yu, Qingqing Yu, Hongbin Liu, Hongbin Liu, Hongbin Liu, Tao Huang, Tao Huang, Tao Huang, Shigang Zhao, Shigang Zhao, Shigang Zhao, Jinlong Ma, Jinlong Ma, Jinlong Ma, Han Zhao, Han Zhao, Han Zhao   +23 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Effect of preconceptional orlistat treatment on in-vitro fertilization outcome in overweight/obese women: study protocol for a randomized controlled trial

Trials, 2018
Background Obese women have fewer oocytes retrieved, an increased cancelation rate, a higher miscarriage rate, and a lower live birth rate after assisted reproductive technology (ART) treatment compared with women with normal weight.
Jing Li, Ze Wang, Daimin Wei, Hong Liu, Jiangtao Zhang, Jianfeng Wang, Yuhua Shi, Zi-Jiang Chen   +7 more
doaj   +1 more source

Commentary: Can Assisted Reproductive Technology (ART) Impact Singapore’s Low Fertility Rate? [PDF]

, 2013
Singapore has consistently posted below-population replacement rates for the past four decades, despite periodic ‘Dragon Year’ spikes, firmly locating it as one of the world’s least fecund societies.
Lee, Geok Ling, Blyth, Eric
core   +1 more source

Safety issues in assisted reproduction technology: The children of assisted reproduction confront the responsible conduct of assisted reproductive technologies [PDF]

Human Reproduction, 2002
Neurological sequelae and multiple birth defects have been observed in children conceived by IVF and ICSI. Multiple pregnancy is the most important risk factor. These health problems challenge the responsible practice of medicine. The core values of medicine and the deontology of the profession have been reviewed to define the responsible conduct of ...
openaire   +2 more sources