Results 71 to 80 of about 318,953 (318)

Effect of preconceptional orlistat treatment on in-vitro fertilization outcome in overweight/obese women: study protocol for a randomized controlled trial

Trials, 2018
Background Obese women have fewer oocytes retrieved, an increased cancelation rate, a higher miscarriage rate, and a lower live birth rate after assisted reproductive technology (ART) treatment compared with women with normal weight.
Jing Li, Ze Wang, Daimin Wei, Hong Liu, Jiangtao Zhang, Jianfeng Wang, Yuhua Shi, Zi-Jiang Chen   +7 more
doaj   +1 more source

Expanded carrier screening in Chinese patients seeking the help of assisted reproductive technology

Molecular Genetics & Genomic Medicine, 2020
Expanded carrier screening (ECS) has emerged as an effective approach to identify at‐risk couples (ARCs)—before they initiate attempts at reproduction—who possess a high probability of having a child affected by severe recessive diseases.
Yanping Xi, Guangquan Chen, Caixia Lei, Junping Wu, Shuo Zhang, Min Xiao, Wenbi Zhang, Yue-ping Zhang, Xiaoxi Sun   +8 more
semanticscholar   +1 more source

Blocking mitochondrial diseases with assisted reproductive technology [PDF]

, 2023
ShiMing LUO, LeiNing CHEN, XiangHong OU, QingYuan SUN   +3 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Efficacy and safety of mesenchymal stem cell therapy for ovarian ageing in a mouse model

Stem Cell Research & Therapy
Background Ovarian ageing is one of the major issues that impacts female fertility. Mesenchymal stem cell (MSC)-based therapy has made impressive progress in recent years.
Wendi Pei, Lin Fu, Wenhuan Guo, Yibo Wang, Yong Fan, Rui Yang, Rong Li, Jie Qiao, Yang Yu   +8 more
doaj   +1 more source

The influence of timing of oocytes retrieval and embryo transfer on the IVF-ET outcomes in patients having bilateral salpingectomy due to bilateral hydrosalpinx

Frontiers in Surgery, 2023
ObjectiveThe objective of the study was to investigate whether the sequence of oocyte retrieval and salpingectomy for hydrosalpinx affects pregnancy outcomes of in vitro fertilization and embryo transfer (IVF-ET) patients.Study DesignThere were 1,610 ...
He Yilei, He Yilei, He Yilei, He Yilei, Yang Shuo, Yang Shuo, Yang Shuo, Yang Shuo, Ma Caihong, Ma Caihong, Ma Caihong, Ma Caihong, Yang Yan, Yang Yan, Yang Yan, Yang Yan, Song Xueling, Song Xueling, Song Xueling, Song Xueling, Zhang Jiajia, Zhang Jiajia, Zhang Jiajia, Zhang Jiajia, Liu Ping, Liu Ping, Liu Ping, Liu Ping, Li Rong, Li Rong, Li Rong, Li Rong, Qiao Jie, Qiao Jie, Qiao Jie, Qiao Jie   +35 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Assisted Reproductive Technology

Encyclopedia of Behavioral Medicine, 2017
Assisted reproductive technology (ART) is the technology used to achieve pregnancy in procedures such as fertility medication, artificial insemination, in vitro fertilization and surrogacy.
B. C. Fauser, D. Braat
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source