Results 101 to 110 of about 5,206,814 (298)

Identification of new genes associated with melanoma

, 2011
Purpose: Repeated failures in melanoma therapy made clear that the molecular mechanisms leading to melanoma are still poorly understood. Here, we aim to provide a more comprehensive understanding of the transcriptional profiles and signaling pathways ...
Mauerer, Andreas
core   +1 more source

The Grief of Peer Loss Among Adolescents: A Narrative Review

Psychology Research and Behavior Management
Xiao-Xue Chen,1 Jing Chen,1,2 Bao-Liang Zhong1,2 1Research Center for Psychological and Health Sciences, China University of Geosciences (Wuhan), Wuhan, People’s Republic of China; 2Department of Psychiatry, Wuhan Mental Health Center, Wuhan, People’s ...
Chen XX, Chen J, Zhong BL
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Magnitude and its associated factors of gestational trophoblastic disease in East African countries, systematic review and meta-analysis

Frontiers in Oncology
BackgroundThe term of gestational trophoblastic disease (GTD) is used to describe a group of tumors that are characterized by abnormal trophoblastic proliferation.
Nigusie Abebaw, Gebeyaw Biset, Nega Yimer, Hailemariyam Gezie, Moges Workneh, Chalie Mulugeta, Tadele Emagneneh, Abebaw Alamrew, Zelalem Birhan   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Early Childhood Cholestasis, Causes & Associated Factors in Children

Diyala Journal of Medicine
Background: Newborn cholestasis is explained as a persisted rise of the serum conjugated bilirubin outside the first two weeks of life. There are many etiologies of newborn cholestasis that must be differentiated since immediate interference may give a ...
Adnan Y. Mahmood , Jalil I. Alezzi, Haider Jwad Dawod, Mabrook Aidah Bin Mohanna   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Factor V Arg306->Gly Mutation Is Not Associated with Activated Protein C Resistance and Is Rare in Taiwanese Chinese

, 2009
Polymerase chain reaction amplification followed by BstO1 enzyme digestion and DNA sequencing was employed to detect the mutation of factor V gene. The subjects consisted of 105 venous thrombophilic patients and 183 healthy controls. Only one patient was
沈銘鏡;林正修;蔡偉, SHEN, MING-CHING;LIN, JEN-SHIOU;TSAY, WOEI   +1 more
core  

Multilevel Analysis of Community Acquired Pneumonia Among 2‐59 Months Old Children in Awi Zone, Northwest Ethiopia: A Community‐Based Cross‐Sectional Study

Health Science Reports
Background and Aims Worldwide, pneumonia was responsible for about 740,180 deaths in children under 5 year, accounting for 14% of all deaths in 2019. The purpose of this study was to identify associated risk factors of community acquired pneumonia among ...
Nigussie Adam Birhan, Alene Yirsaw Workineh, Gedif Mulat Alemayehu, Zelalem Meraf Wolde, Chalachew Alemie Messfin   +4 more
doaj   +1 more source