Results 111 to 120 of about 124,424 (305)

Meta-Potentiation: Neuro-Astroglial Interactions Supporting Perceptual Consciousness

, 2007
Conscious perceptual processing involves the sequential activation of cortical networks at several brain locations, and the onset of oscillatory synchrony affecting the same neuronal population.
Fábio Augusto Furlan, Alfredo Pereira Jr   +1 more
core  

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Astrocyte model variables.

, 2018
Astrocyte model variables.
Bronac Flanagan (5105390), Kevin Breslin (5236643), KongFatt Wong-Lin (217053), Jim Harkin (189927), Alexei Verkhratsky (377042), John Joseph Wade (5236634), Liam McDaid (5105387), Harm Van Zalinge (5236640), Steve Hall (5236637), Matthew Walker (343875)   +9 more
core   +1 more source

Spatiotemporal Drug Delivery via a Neonatal Spinal Cord ECM Hydrogel for Biomimetic Microenvironment Remodeling After Spinal Cord Injury

Advanced Functional Materials, EarlyView.
A biomimetic hydrogel derived from neonatal spinal cord ECM (DNSCM) delivers LAMB2 protein and ISP peptide to remodel the inhibitory injury microenvironment. The system sustains drug release, upregulates pro‐regenerative LAMB2, downregulates inhibitory CSPG, and promotes axonal regeneration.
Shiyu Fu, Liangchao Du, Runlin Wen, Kai Zhang, Yu Zhou, Wanrong Ma, Zhiquan Yang, Dingyang Liu, Xing Li   +8 more
wiley   +1 more source

Astrocyte model parameters.

, 2018
Astrocyte model parameters.
Bronac Flanagan (5105390), Kevin Breslin (5236643), KongFatt Wong-Lin (217053), Jim Harkin (189927), Alexei Verkhratsky (377042), John Joseph Wade (5236634), Liam McDaid (5105387), Harm Van Zalinge (5236640), Steve Hall (5236637), Matthew Walker (343875)   +9 more
core   +1 more source

Astrocytes from P301S Tau mice exhibit non-canonical protein secretion and reduced morphological complexity

Neural Regeneration Research
Astrocytes have important neurosupportive functions in the brain that are altered in neurodegenerative diseases by unresolved mechanisms. We showed previously that astrocytes cultured from mice transgenic for human P301S-tau (P301S-mice) recapitulate the
Aishwarya G. Nadadhur, Matthew Mason, Johanna S. Rees, Marta Sidoryk-Wegrzynowicz, Aviva M. Tolkovsky, Maria Grazia Spillantini   +5 more
doaj   +1 more source

Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats

Advanced Functional Materials, EarlyView.
We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang, Ilya Pyatnitskiy, Yanshu Shi, Kai Wing Kevin Tang, Yi Xie, Sihan Yu, Thomas Wynn, Xiangping Liu, Ju‐Chun Hsieh, Jinmo Jeong, Weilong He, Brinkley Artman, Anakaren Romero Lozano, Xi Shi, Arjun Sangani, Lief E Fenno, Samantha Santacruz, Banglin Chen, Huiliang Wang   +18 more
wiley   +1 more source

Astrocyte-Conditioned Medium Induces Protection Against Ischaemic Injury in Primary Rat Neurons

Background: Astrocytes are not only structural cells but also play a pivotal role in neurogenesis and neuroprotection by secreting a variety of neurotrophic factors that support neuronal survival, growth, and repair.
Singh, Ayesha, Chen, Ruoli
core   +1 more source

Study of a novel regulatory mechanism underlying expression of an astrocyte-spefic gene Gfap [PDF]

, 2013
奈良先端科学技術大学院大学博士(バイオサイエンス)doctoral ...
裏山, 悟司, 26944, Urayama, Satoshi, ウラヤマ, サトシ   +3 more
core  

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source