Results 131 to 140 of about 124,424 (305)

Soft Neural Interfaces for Circuit‐Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models

Advanced Healthcare Materials, EarlyView.
ABSTRACT Magnetogenetic deep brain stimulation (MG‐DBS) represents a wireless neuromodulation that has demonstrated long‐lasting behavioral benefits in Parkinson's disease models. However, the circuit‐level mechanisms underlying these therapeutic effects have remained uncharacterized due to limitations of conventional neural interfaces.
Jakyoung Lee, Yeongdo Lee, Enji Kim, Hunkyu Seo, Myoungjae Oh, Hanho Joo, Somin Lee, Jae‐Hyun Lee, Hyun Ho Jung, Minsuk Kwak, Jang‐Ung Park   +10 more
wiley   +1 more source

Dysfunctional astrocyte-neuron signaling in Major Depressive Disorder

Major depressive disorder (MDD) is a severe and debilitating mental illness with a very large socioeconomic impact worldwide1. The neurobiology of this disease has been studied for a long time, focused on neuron alterations; however, the underlying ...
Perea, Gertrudis
core  

Endocannabinoids Mediate Neuron-Astrocyte Communication

, 2008
SummaryCannabinoid receptors play key roles in brain function, and cannabinoid effects in brain physiology and drug-related behavior are thought to be mediated by receptors present in neurons.
Araque, Alfonso, Navarrete, Marta
core   +1 more source

Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson’s disease through Mfn2-cGAS signaling

Journal of Neuroinflammation
Background Senescent astrocytes play crucial roles in age-associated neurodegenerative diseases, including Parkinson’s disease (PD). Metformin, a drug widely used for treating diabetes, exerts longevity effects and neuroprotective activities.
Min Wang, Tian Tian, Hong Zhou, Si-Yuan Jiang, Ying-Ying Jiao, Zhu Zhu, Jiang Xia, Jian-Hua Ma, Ren-Hong Du   +8 more
doaj   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

ATF3 Knockdown Exacerbates Astrocyte Activation by Inhibiting Phosphorylation of Drp1 in Ischemic Stroke

Rong Huang,1 Xiaoyan Huang,1 Hongmei Yang,1 Haixuan Wu,1 Fan Liu,1 Phei Er Saw,2,3 Minghui Cao1,4 1Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 2Medical Research ...
Yang H, Saw PE, Cao M, Huang X, Huang R, Liu F, Wu H   +6 more
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Long‐Term Hydrophilic, Anti‐Clotting, and Anti‐Fibrotic Dynamic Covalent Silicone‐Based Biomaterials

Advanced Healthcare Materials, EarlyView.
Dynamic covalent crosslinking of a Schiff‐base silicone elastomer with hydrazide‐functionalized polymers is demonstrated to improve the long‐term hydrophilicity as well as the anti‐fouling and anti‐clotting properties of PDMS implants. The hydrazone‐functionalized material prevents hydrophobic recovery, resists clotting, and significantly reduces ...
Norma A. Garza Flores, Eva Mueller, Robert Bui, James C. Fredenburgh, Ruiqi Yin, Rawaa Hussain, Rida A. Malik, Thomas Kalab, Dabeer Abdul‐Azeez, Fei Xu, Michael Brook, Jeffrey I. Weitz, Todd Hoare   +12 more
wiley   +1 more source

Hyperglycemia Alters Astrocyte Metabolism and Inhibits Astrocyte Proliferation

, 2018
Diabetes milieu is a complex metabolic disease that has been known to associate with high risk of various neurological disorders. Hyperglycemia in diabetes could dramatically increase neuronal glucose levels which leads to neuronal damage, a phenomenon ...
Yang, Shaohua, Li, Wenjun, Lin, Wenping, Liu, Ran, Prah, Jude, Roy Choudhury, Gourav, Winters, Ali   +6 more
core   +1 more source

Dexime: A Selectively Enzyme‐Degradable Hydrogel for Protein Therapeutic Release

Advanced Materials, EarlyView.
A dextrin‐oxime hydrogel (dexime) is produced using ketone or aldehyde modified dextrin and tetra‐oxyamine modified poly(ethylene glycol). The rheological and mechanical properties of dexime are tunable. Dexime is injectable, cytocompatible, hydrolytically stable, and selectively degradable by α‐amylase.
Quinton E. A. Sirianni, Nitzan Letko Khait, Adam Forman, Edward A. Armstrong, Karim Fouad, Molly S. Shoichet   +5 more
wiley   +1 more source

Astrocyte Biomarkers in Alzheimer's Disease

, 2019
Astrocytic contributions to Alzheimer's disease (AD) progression were, until recently, largely overlooked. Astrocytes are integral to normal brain function and astrocyte reactivity is an early feature of AD, potentially providing a promising target for ...
Nordberg, A,, Zimmer, ER, Zimmer, Eduardo, R, Carter, Stephen F, Herholz, K, Nordberg, A., Zimmer, Eduardo,, Carter, SF, Zimmer, E.R., Rosa-Neto, P, Herholz, Karl; id_orcid, Herholz, Karl, Carter, Stephen,, CARTER, Stephen, Rosa-Neto, Pedro, Herholz, K., Rosa-Neto, P., Nordberg, Agneta, Carter, Stephen, F, Pellerin, L, Pellerin, L., Zimmer, Eduardo R, Pellerin, Luc, Carter, S.F., ZIMMER, Eduardo   +24 more
core   +1 more source