Results 161 to 170 of about 194,703 (370)

Epilepsy and astrocyte energy metabolism

Glia, 2018
Epilepsy is a complex neurological syndrome characterized by neuronal hyperexcitability and sudden, synchronized electrical discharges that can manifest as seizures.
D. Boison, C. Steinhäuser
semanticscholar   +1 more source

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

Advanced Science, EarlyView.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li, Shuhan Jin, Danke Wang, Ying Wu, Xiaoyu Tang, Yufan Liu, Tiange Yao, Shoufa Han, Lin Sun, Yuetong Wang, Steven X. Hou   +10 more
wiley   +1 more source

Nanomaterials as therapeutic agents to modulate astrocyte-mediated inflammation in spinal cord injury

Materials Today Bio, 2023
Promoting the recovery of neurological function in patients with traumatic spinal cord injury (TSCI) remains challenging. The balance between astrocyte-mediated neurotrophic and pro-inflammatory responses is critical for TSCI repair.
Wenqi Luo, Yueying Li, Chunyu Xiang, Toshimi Aizawa, Renrui Niu, Yiming Wang, Jianhui Zhao, Zeping Liu, Chaoyuan Li, Wanguo Liu, Rui Gu   +10 more
doaj  

Ultrasound‐Assisted H2 Transmitter Enables Hydrogen‐Gene Therapy to Prevent Anesthesia/Surgery‐Induced Cognitive Impairment

Advanced Science, EarlyView.
Postoperative cognitive dysfunction (POCD) remains a challenge with no effective treatments. This study introduces a novel hydrogen‐gene therapy strategy, combining focused ultrasound and siRNA delivery via hydrogen emitters, to repair neuroinflammation in a precise and controlled manner.
Ruonan Zhan, Yan Fang, Chuyun Lou, Nan Chen, Xuan Mo, Bo Jiao, Mengke Liu, Yangxi Zhao, Weichen Xu, Huixiong Xu, Haohao Yin, Yi Zhang   +11 more
wiley   +1 more source

Characterizing Learning in Spiking Neural Networks with Astrocyte-Like Units [PDF]

arXiv
Traditional artificial neural networks take inspiration from biological networks, using layers of neuron-like nodes to pass information for processing. More realistic models include spiking in the neural network, capturing the electrical characteristics more closely.
arxiv  

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

Advanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han, Rui Hong, Cong Cao, Wanhua Feng, Wei Zhuang, Gui Wang, Jingchao Tang, Ya Yang, Chu Zhang, Aihua Zhou, Xuebin Qu   +10 more
wiley   +1 more source

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

Nature Neuroscience, 2020
O. Bayraktar, Theresa Bartels, S. Holmqvist, Vitalii Kleshchevnikov, A. Martirosyan, D. Polioudakis, L. Ben Haim, Adam M. H. Young, M. Batiuk, Kirti Prakash, Alexander Brown, Kenny Roberts, Mercedes F. Paredes, R. Kawaguchi, J. Stockley, Khalida Sabeur, Sandra M. Chang, E. Huang, P. Hutchinson, E. Ullian, M. Hemberg, G. Coppola, M. Holt, D. Geschwind, D. Rowitch   +24 more
semanticscholar   +1 more source

A rapid silver impregnation technique for oligodendrocytes, microglia, and astrocytes. [PDF]

, 1971
T. Scott
openalex   +1 more source

Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors

Advanced Science, EarlyView.
PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao, Zhongkun Zhang, Minzi Ju, Liang Bian, Huijuan Wang, Sibo Zhao, Ningbo Cai, Yu Wang, Yanpeng Jia, Ling Shen, Yuan Zhang, Honghong Yao   +11 more
wiley   +1 more source

Excitatory amino acid-stimulated uptake of 22Na+ in primary astrocyte cultures [PDF]

, 1989
HK Kimelberg, K. Sandy Pang, DH Treble
openalex   +1 more source