Results 181 to 190 of about 283,599 (345)
Advanced Science, EarlyView.The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi +15 more
wiley +1 more source
Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS [PDF]
, 2013 Kathrin Meyer +14 more
openalex +1 more source
iPSC-Astrocyte morphology reflects patient clinical markers [PDF]
, 2023 Helen Rowland +25 more
openalex +1 more source
Advanced Science, EarlyView.This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang +20 more
wiley +1 more source
Correction: Induced Overexpression of Connexin43 in Astrocytes Attenuates the Progression of Experimental Temporal Lobe Epilepsy [PDF]
Oussama Kherbouche +8 more
openalex +1 more source
Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions
Advanced Science, EarlyView.Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley +1 more source
Microglia Are More Efficient Than Astrocytes in Antigen Processing and in Th1 But Not Th2 Cell Activation [PDF]
, 1998 Francesca Aloisi +3 more
openalex +1 more source
Advanced Science, EarlyView.This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu +17 more
wiley +1 more source
“Kiss-and-Run” Glutamate Secretion in Cultured and Freshly Isolated Rat Hippocampal Astrocytes [PDF]
, 2005 Xiaoke Chen +4 more
openalex +1 more source
Advanced Science, EarlyView.A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni +6 more
wiley +1 more source