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Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis [PDF]

open access: yesNature, 2017
Astrocytes are complex glial cells with numerous fine cellular processes that infiltrate the neuropil and interact with synapses. The mechanisms that control the establishment of astrocyte morphology are unknown, and it is unclear whether impairing astrocytic infiltration of the neuropil alters synaptic connectivity.
Katherine T Baldwin   +2 more
exaly   +3 more sources
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Astrocytes

Current Biology, 2021
Philip Hasel and Shane Liddelow introduce astrocytes - glial cells that help to maintain the homeostasis of the central nervous system during development, normal physiology, and aging.
Philip, Hasel, Shane A, Liddelow
openaire   +2 more sources

Astrocytes and Epilepsy

Neurochemical Research, 2021
Changes in astrocyte channels, transporters, and metabolism play a critical role in seizure generation and epilepsy. In particular, alterations in astrocyte potassium, glutamate, water and adenosine homeostasis and gap junctional coupling have all been associated with hyperexcitability and epileptogenesis (largely in temporal lobe epilepsy).
Devin K. Binder, Christian Steinhäuser
openaire   +2 more sources

Astrocytes and Behavior

Annual Review of Neuroscience, 2021
Animal behavior was classically considered to be determined exclusively by neuronal activity, whereas surrounding glial cells such as astrocytes played only supportive roles. However, astrocytes are as numerous as neurons in the mammalian brain, and current findings indicate a chemically based dialog between astrocytes and neurons.
Paulo, Kofuji, Alfonso, Araque
openaire   +2 more sources

Plasticity of astrocytes

Glia, 1994
AbstractIt is becoming apparent that astrocytes carry out a large number of different functions in brain and are able to modify their characteristics throughout life, that is they exhibit a high degree of plasticity in their phenotype. For example, the morphology of astrocytes changes markedly during neuronal migration, maturation, and degeneration. It
Y, Shao, K D, McCarthy
openaire   +2 more sources

Astrocytes in Ageing

2023
Ageing is associated with a morphological and functional decline of astrocytes with a prevalence of morphological atrophy and loss of function. In particular, ageing is manifested by the shrinkage of astrocytic processes: branches and leaflets, which decreases synaptic coverage.
Verkhratsky, Alexei, Semyanov, Alexey
openaire   +4 more sources

Physical Memory of Astrocytes

SSRN Electronic Journal, 2022
Traumatic brain injury (TBI) is a major risk factor for development of neurodegenerative disorders later in life. Short, repetitive, mechanical impacts can lead to pathology that appears days or months later. The cells have a physical "memory" of mechanical events. The origin of this memory is not known.
Tasnim, Shireen   +2 more
openaire   +2 more sources

Astrocytes and Astrocyte–Neuron Interactions

2021
Abstract Astrocytes constitute approximately 30 percent of cells in the CNS and are the most abundant glial cells. They constitute a structural and functionally heterogeneous population and are critically involved in development, homeostasis, synaptic and neuronal network activity, and response to injury and repair in the CNS.
openaire   +1 more source

Astrocytes in Migration

Neurochemical Research, 2016
Cell migration is a fundamental phenomenon that underlies tissue morphogenesis, wound healing, immune response, and cancer metastasis. Great progresses have been made in research methodologies, with cell migration identified as a highly orchestrated process.
Jiang Shan Zhan   +9 more
openaire   +2 more sources

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