Results 321 to 330 of about 283,599 (345)

Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m6A‐IGF2BP1 for Ischemic Stroke Rescue

Advanced Science, EarlyView.
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li, Yong‐Dong Guo, Xiao‐Wen Zhang, Zhi‐Yong Du, Yu‐Qi Wang, Zhuo Yang, Qian‐Wei Luo, Fang‐Fang Zhuo, Tian‐Tian Wei, Zheng‐Ping Liu, Bo Han, Wei Yu, Pei‐Pei Zhang, Wei Zhou, Zhi‐Yuan Lu, Peng‐Fei Tu, Chun‐Hong Zheng, Ke‐Wu Zeng   +17 more
wiley   +1 more source

Astrocyte Transcriptomics in a Three-Dimensional Tissue-Engineered Rostral Migratory Stream. [PDF]

Cells
Grovola MR, Purvis EM, Garcia-Epelboim AD, Krizman EN, O'Donnell JC, Cullen DK.   +5 more
europepmc   +1 more source

Enhanced Protein Synthesis and Hippocampus‐Dependent Memory via Inhibition of YTHDF2‐Mediated m6A mRNA Degradation

Advanced Science, EarlyView.
YTHDF2‐mediated m6A mRNA decay critically regulates learning and memory. Its forebrain‐specific knockout in mice impedes degradation of m6A‐modified mRNAs, enhancing hippocampal synaptic transmission, protein synthesis, and memory. Conversely, hippocampal YTHDF2 reintroduction or SEMA4B reduction reverses this enhancement, while its overexpression ...
Kuan Li, Chen Guo, Xiaoli Wu, Cuiting Wu, Songfen Wu, Si Su, Min Wu, Xidan Zhou, Si Li, Yihui Cui, Tao Zhou   +10 more
wiley   +1 more source

Hydroxysafflor Yellow A Reduced Neuroinflammation Induced by Astrocyte-Derived IL-17A by Inhibiting the IL-17RA/ACT1/NF-κB/IL-17A Loop After OGD/R. [PDF]

J Inflamm Res
Song L, Hua J, Liu K, Duan Y, Sun Y, Yu J, Yin J, Ma C, Xiao B, Ma D, Huang J.   +10 more
europepmc   +1 more source

Developmental regulation of long-range neuroblast migration by Eph/ephrin signaling. [PDF]

Front Neurosci
Yeroshenko D, de Silva C, Burli A, Bellizzi S, Singh V, Conover J.   +5 more
europepmc   +1 more source

Connexin43 and Its Regulation of Astrocyte Gap Junction Function: Influencing Depression Progression by Mediating Electrical and Chemical Signals. [PDF]

CNS Neurosci Ther
Wang H, Chen C, Lin Y, Tian Z, Yan Z, Zeng X, Yang Y, Lin M, Ai Q, Liu X, Yang S, Chen N.   +11 more
europepmc   +1 more source

From synaptic gatekeepers to affective-cognitive modulators: The astrocyte D1 receptor-d-serine axis in the prefrontal cortex. [PDF]

Acta Pharm Sin B
Fang LP, Kirchhoff F.
europepmc   +1 more source

Mycobacterium tuberculosis-induced oligodendrocyte apoptosis promotes astrocyte-mediated cell-in-cell formation and phagocytosis in tuberculous meningitis. [PDF]

BMC Infect Dis
Feng J, Qiu F, Niu Z, Fang M, Yang J, Xiao L, Zhao J, Sun Q, Zhang J.   +8 more
europepmc   +1 more source

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Neuroinflammatory astrocyte subtypes in the mouse brain

Nature Neuroscience, 2021
Philip Hasel, Indigo V L Rose, Jessica S Sadick   +2 more
exaly   +2 more sources