Results 321 to 330 of about 176,729 (360)

Hes5⁺ astrocytes potentiate primary afferent Aδ and C fiber-mediated excitatory synaptic transmission to spinal lamina I neurons. [PDF]

Mol Brain
Kagiyama I, Uchiyama S, Tsuda M.
europepmc   +1 more source

Ethnomedicinal uses, phytochemistry, pharmacological activities, and toxicology of the subfamily Gomphrenoideae (Amaranthaceae): A comprehensive review

Chemistry &Biodiversity, Accepted Article.
The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its promising ...
Dayanna Isabel Araque Gelves, Giulia Cristina Andreoli de Souza, Alvaro Jose Hernandez Tasco, Marcos Jose Salvador   +3 more
wiley   +1 more source

Reactive Astrocytes Release GDNF to Promote Brain Recovery and Neuronal Survival Following Ischemic Stroke. [PDF]

Neurochem Res
Zhang Z, Zhang N, Ding S.
europepmc   +1 more source

Insulin and Metformin are Associated With Reduced Risk of Amyotrophic Lateral Sclerosis

Chronic Diseases and Translational Medicine, EarlyView.
Human insulin heterodimer (A). Human insulin heterodimer (dark blue) docked within center of Cx43 channel (B) Abstract Background Type 2 diabetes (T2D), but not type 1, protected against amyotrophic lateral sclerosis (ALS). In T2D serum insulin is normal or elevated in the early stages.
Steven Lehrer, Peter H. Rheinstein
wiley   +1 more source

Amelioration of Astrocytic Dysfunction via AQP4/LRP1 Pathway by <i>Zizania latifolia</i> and Tricin in C6 Cells Exposed to Amyloid β and High-Dose Insulin and in Mice Treated with Scopolamine. [PDF]

J Microbiol Biotechnol
Yang SA, Park SH, Kim EH, Bae WB, Jhee KH.   +4 more
europepmc   +1 more source

Amyloid‐Related Imaging Abnormality (ARIA) Beyond the APOE‐ε4 Allele

Chronic Diseases and Translational Medicine, EarlyView.
Mechanism of action of monoclonal antibodies targeting Aβ in the treatment of AD. (A) Targets of various mAbs. (B) Mechanism of monoclonal antibody‐mediated clearance of Aβ. mAbs facilitate the clearance of Aβ by enhancing microglial‐mediated phagocytosis through the upregulation of TREM2 expression.
Valentinus Besin, Farizky Martriano Humardani, Fenny Lanawati Yudiarto, Paulus Anam Ong, Sulistyo Emantoko Dwi Putra, Ratih Asmana Ningrum   +5 more
wiley   +1 more source

Lysosomal acidification impairment in astrocyte-mediated neuroinflammation. [PDF]

J Neuroinflammation
Zeng J, Indajang J, Pitt D, Lo CH.
europepmc   +1 more source

Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation. [PDF]

Elife
Guayasamin M, Depaauw-Holt LR, Adedipe II, Ghenissa O, Vaugeois J, Duquenne M, Rogers B, Latraverse-Arquilla J, Peyrard S, Bosson A, Murphy-Royal C.   +10 more
europepmc   +1 more source

Distinct astrocyte activation patterns associated with neuroinflammation induced by gamma and proton beam irradiation. [PDF]

Sci Rep
Yan L, Er T, Sun S, Deng Y, Wan Z, Zhao J, Wang A, Liu B, Wang Q, Sui L, Ma H.   +10 more
europepmc   +1 more source

Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost, Jeremy Y. Huang, Georgia Dermentzaki, Anna S. Blazier, Giorgio Gaglia, Timothy R. Hammond, Francesca Frau, Mary Clare McCorry, Dimitry Ofengeim, Jennifer L. Wilson   +9 more
wiley   +1 more source