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Astrocyte dysfunction in epilepsy
Brain Research Reviews, 2010Epilepsy comprises a group of disorders characterized by the periodic occurrence of seizures. Currently available anticonvulsant drugs and therapies are insufficient to controlling seizure activity in about one third of epilepsy patients. Thus, there is an urgent need for new therapies that prevent the genesis of the disorder and improve seizure ...
Christian Steinhäuser+2 more
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Astrocytes and Astrocyte–Neuron Interactions
2021Abstract Astrocytes constitute approximately 30 percent of cells in the CNS and are the most abundant glial cells. They constitute a structural and functionally heterogeneous population and are critically involved in development, homeostasis, synaptic and neuronal network activity, and response to injury and repair in the CNS.
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2009
Astrocytic gliomas are the most common primary brain tumors and account for up to two thirds of all tumors of glial origin. In this review we outline the basic histological and epidemiological aspects of the different astrocytoma subtypes in adults. In addition, we summarize the key genetic alterations that have been attributed to astrocytoma patho ...
Markus J, Riemenschneider+1 more
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Astrocytic gliomas are the most common primary brain tumors and account for up to two thirds of all tumors of glial origin. In this review we outline the basic histological and epidemiological aspects of the different astrocytoma subtypes in adults. In addition, we summarize the key genetic alterations that have been attributed to astrocytoma patho ...
Markus J, Riemenschneider+1 more
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Role of PACAP in Astrocytes and Astrocytic Tumors
2016In the central nervous system (CNS), astrocytes are the most numerous among glial cells and have diverse physiological functions. These cells also play an important role in many CNS disorders and pathologies. Pituitary adenylate cyclase activating polypeptide (PACAP) is abundantly expressed in the CNS, acting as a neuroprotectant against various ...
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