Results 251 to 260 of about 273,908 (305)

Astrocyte Senescence Disrupts the Extracellular Mitochondrial Compartment and Compromises Bioenergetic Support to Human Neurons. [PDF]

Antioxidants (Basel)
Amorim P, Hayashide LS, Leocadio VE, Marques M, Navarra I, Andrade CBV, de Carvalho JJ, Pinto RS, Diniz LP.   +8 more
europepmc   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Targeted neuronal stimulation modulates working memory via astrocytic interactions: Insights from a spiking neuron-astrocyte model. [PDF]

iScience
Naghieh P, Amiri M, Peremans H.
europepmc   +1 more source

Longitudinal Awake Mouse Brain Imaging Using Functional Ultrasound and Functional Ultrasound Localization Microscopy

Advanced Science, EarlyView.
Awake longitudinal multimodal ultrasound imaging integrates functional ultrasound (fUS), ultrasound localization microscopy (ULM), and functional ULM (fULM) to characterize cerebrovascular function, microvascular architecture, and flow dynamics within the same animals over time.
Zhe Huang, Yike Wang, Matthew R. Lowerison, Yue Xu, Murong Yi, Bing‐Ze Lin, YiRang Shin, Nathiya Vaithiyalingam Chandra Sekaran, Daniel A. Llano, Pengfei Song   +9 more
wiley   +1 more source

Written in the Stars: Astrocyte Biology From Evolution to Disease. [PDF]

Acta Physiol (Oxf)
Falcone C, Arckens L, Baiula M, Bedini A, Bocchi R, Broadhead MJ, Caprini M, Cavaliere F, Cesca F, Chowdhury HH, Ciuba K, Civiero L, Escartin C, Ferroni S, Formaggio F, Frasca A, Gratton R, Holt M, Iraci N, Kreft M, Leggio L, Lia A, Malik AR, Min R, Müller FE, Murat C, Pereira MJ, Pekowska A, Petrelli F, Ramos-Gonzalez P, Sanchez-Mico MV, Smole Z, Sokolova D, Solas M, Soldano A, Szewczyk LM, Torazza C, Severino FPU, Urrestizala-Arenaza N, Zeug A, Zhou J, Zonta M, Zorec R, Verkhratsky A, Gunhanlar N.   +44 more
europepmc   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

ER Stress Regulates HIV Tat and Alcohol-Induced NLRP6 Activation in Astrocytes. [PDF]

CNS Neurosci Ther
Singh S, Horanieh E, Buch S, Periyasamy P.   +3 more
europepmc   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Astrocytic Neuroligins Control Astrocyte Morphogenesis and Synaptogenesis [PDF]

Nature, 2017
Astrocytes are complex glial cells with numerous fine cellular processes that infiltrate the neuropil and interact with synapses. The mechanisms that control the establishment of astrocyte morphology are unknown, and it is unclear whether impairing astrocytic infiltration of the neuropil alters synaptic connectivity.
Eray Enüstün, Katherine T Baldwin, Çağla Eroğlu   +2 more
exaly   +3 more sources