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Modeling CLN3 Batten disease in astrocytes reveals alterations in mitochondria homeostasis, fatty acid metabolism and oxidative stress response. [PDF]

open access: yesJ Biomed Sci
Yang M   +12 more
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Astrocytes

Current Biology, 2021
Philip Hasel and Shane Liddelow introduce astrocytes - glial cells that help to maintain the homeostasis of the central nervous system during development, normal physiology, and aging.
Philip, Hasel, Shane A, Liddelow
openaire   +2 more sources

Astrocytes and Behavior

Annual Review of Neuroscience, 2021
Animal behavior was classically considered to be determined exclusively by neuronal activity, whereas surrounding glial cells such as astrocytes played only supportive roles. However, astrocytes are as numerous as neurons in the mammalian brain, and current findings indicate a chemically based dialog between astrocytes and neurons.
Paulo Kofuji, Alfonso Araque
exaly   +3 more sources

Astrocytes and Epilepsy

Neurochemical Research, 2021
Changes in astrocyte channels, transporters, and metabolism play a critical role in seizure generation and epilepsy. In particular, alterations in astrocyte potassium, glutamate, water and adenosine homeostasis and gap junctional coupling have all been associated with hyperexcitability and epileptogenesis (largely in temporal lobe epilepsy).
Devin K. Binder, Christian Steinhäuser
openaire   +2 more sources

Plasticity of astrocytes

Glia, 1994
AbstractIt is becoming apparent that astrocytes carry out a large number of different functions in brain and are able to modify their characteristics throughout life, that is they exhibit a high degree of plasticity in their phenotype. For example, the morphology of astrocytes changes markedly during neuronal migration, maturation, and degeneration. It
Y, Shao, K D, McCarthy
openaire   +2 more sources

Astrocytes in Ageing

2023
Ageing is associated with a morphological and functional decline of astrocytes with a prevalence of morphological atrophy and loss of function. In particular, ageing is manifested by the shrinkage of astrocytic processes: branches and leaflets, which decreases synaptic coverage.
Verkhratsky, Alexei; id_orcid 0000-0003-2592-9898   +1 more
openaire   +4 more sources

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