Results 301 to 310 of about 461,223 (386)

RPS3‐Enriched Extracellular Vesicles Mediate Liver‐Spinal Cord Inter‐Organ Communication

Advanced Science, EarlyView.
Spinal cord injury activates the liver to send extracellular vesicles loaded with RPS3 protein to the lesion site. These vesicles are taken up by neural stem cells and astrocytes, triggering NF‐κB signaling, impairing the regeneration of neurons and myelin, and promotes harmful inflammation, ultimately hindering recovery.
Peiwen Song, Zuomeng Wu, Yixiang Dong, Yunxiong Fang, Shiyu Bian, Daokuan Wang, Huang Fang, Yunlei Liu, Wang Ying, Jun Qian, Tianyu Han, Cailiang Shen   +11 more
wiley   +1 more source

NEO1 modulates the A1 astrocyte polarization in subarachnoid hemorrhage through the cPLA2-MAVS signaling pathway. [PDF]

J Neuroinflammation
Wu Y, Wei B, Jin L, Li L, Yang Z, Li C, Zhou J, Gong W, Feng X, Guo S, Cheng W, Li R, Liang S, Su S, Jin F, Zhang X, Liu Y, Duan C, Li X, Liu W.   +19 more
europepmc   +1 more source

Data‐Driven Feedback Identifies Focused Ultrasound Exposure Regimens for Improved Nanotheranostic Targeting of the Brain

Advanced Science, EarlyView.
ABSTRACT The blood‐brain barrier (BBB) renders the delivery of nanomedicine in the brain ineffective and the detection of circulating disease‐related DNA from the brain unreliable. Here, we demonstrate that microbubble‐enhanced focused ultrasound (MB‐FUS) mediated BBB opening, supported by large‐data models predict sonication regimens for safe and ...
Hohyun Lee, Victor Menezes, Shiqin Zeng, Chulyong Kim, Cynthia M. Baseman, Jae Hyun Kim, Samhita Padmanabhan, Pranav Premdas, Naima Djeddar, Anton Bryksin, Nikhil Pandey, Pavlos Anastasiadis, Anthony J. Kim, Tobey J. MacDonald, Chetan Bettegowda, Graeme F. Woodworth, Felix J. Herrmann, Costas Arvanitis   +17 more
wiley   +1 more source

Emerging roles of astrocytes in hippocampal circuitry and behavior. [PDF]

Front Cell Neurosci
Squires A, Park J.
europepmc   +1 more source

Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase

Advanced Science, EarlyView.
Overview of Sructure, Multienzyme‐mimicking Activity and Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase. Abstract Redox dysregulation is recognized as a key driver in the pathophysiology of numerous refractory diseases, contributing significantly to the progression and poor prognosis.
Kai Song, Yu Wei, Peng Jia, Shan He, Qian Wang, Manman Xu, Hongzhi Liu, Pengtao Bao, Shanyue Guan, Xiaozhong Qu   +9 more
wiley   +1 more source

Astrocytic SIRT1 ameliorates cognitive deficits after traumatic brain injury via autophagy-mediated MEGF10 phagocytosis. [PDF]

J Neuroinflammation
Ji Q, Zhang Y, Zhang Z, Cui K, Zhao L, Sun X, Qu H, Song J, Xiao J, Zhang X, Lu Y, Xu J, Li D.   +12 more
europepmc   +1 more source

Image 4_Automated radiosynthesis and clinical experience of [18F]SMBT-1 PET imaging for in vivo evaluation of reactive astrocyte in Parkinson's disease: a pilot study.tiff

Peerapon Kiatkittikul (22801874), Pradith Lerdsirisuk (22801877), Laksika Bhuthathorn (22801880), Arthita Choolam (22801883), Attapon Jantarato (9326857), Pattanapong Kongsakorn (22801886), Wisakha Chintawan (22801889), Thanapon Sringam (22801892), Nirawan Fonghoi (22801895), Saiphet Vanprom (22801898), Ryuichi Harada (812729), Nobuyuki Okamura (812727), Shozo Furumoto (812728), Chetsadaporn Promteangtrong (6127508)   +13 more
openalex   +1 more source

“Time Is Brain” – for Cell Therapies

Advanced Science, EarlyView.
The concept that “time is brain” extends to stem cell therapy for stroke. Evidence across preclinical and clinical studies indicates that delivery timing shapes graft survival, integration, and efficacy by matching the evolving post‐stroke microenvironment.
Hao Yin, Dominikus Brian, Rebecca Z. Weber, Patrick D. Lyden, Ruslan Rust   +4 more
wiley   +1 more source

Neuron-Glia Crosstalk in the Regulation of Astrocytic Antioxidative Mechanisms Following CNS Injury. [PDF]

Antioxidants (Basel)
Zakrzewski PK, Boczek T.
europepmc   +1 more source

Immunoaffinity‐Mimetic Assembly of Peptide‐Aptamer Conjugates and Stem Cell‐Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair

Advanced Science, EarlyView.
Inspired by antibody‐antigen binding, this study develops an unprecedented immunoaffinity‐mimetic assembly strategy, with Peptide‐AptCD63 conjugates acting as antibody surrogates binding CD63 epitopes on mesenchymal stem cell‐derived exosomes. This creates a hierarchical microstructure intended to synergistically integrate antioxidative and anti ...
Dantong Zheng, Yuxin Bai, Zhibo Liu, Zinan Zhao, Yiming Kong, Yao Xu, Qi Jia, Rongrong Zhu, Yong Hu   +8 more
wiley   +1 more source