Results 111 to 120 of about 109,064 (360)

Multiclass Spinal Cord Tumor Segmentation on MRI with Deep Learning [PDF]

arXiv, 2020
Spinal cord tumors lead to neurological morbidity and mortality. Being able to obtain morphometric quantification (size, location, growth rate) of the tumor, edema, and cavity can result in improved monitoring and treatment planning. Such quantification requires the segmentation of these structures into three separate classes.
arxiv  

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

Ibrain, EarlyView.
Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka, Mariafrancesca Cascione, Paolo Pellegrino, Annalisa Bianco, Stefano Leporatti, Valeria De Matteis   +5 more
wiley   +1 more source

The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation. [PDF]

, 2017
Low-grade gliomas are one of the most common brain tumors in children, where they frequently form within the optic pathway (optic pathway gliomas; OPGs).
Castillon, Guillaume A, Cimino, Patrick J, Ellisman, Mark H, Gianino, Scott M, Gutmann, David H, Lee, Da Yong, Ma, Yu, Pan, Yuan, Solga, Anne C, Toonen, Joseph A   +9 more
core   +3 more sources

Prognostic Roles of Central Carbon Metabolism–Associated Genes in Patients With Low-Grade Glioma

Frontiers in Genetics, 2019
Purpose: Metabolic alterations are crucial for tumor progression and response to therapy. The comprehensive model of combined central carbon metabolism–associated genes that contribute to the outcomes of glioma and astrocytoma is not well understood ...
Li Wang, Meng Guo, Kai Wang, Lei Zhang
doaj   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Salvage Fractionated Stereotactic Re-irradiation (FSRT) for Patients with Recurrent High Grade Gliomas Progressed after Bevacizumab Treatment [PDF]

, 2017
Purpose/Objectives: Bevacizumab failure is a major clinical problem in the manage- ment of high grade gliomas (HGG), with a median overall survival of less than 4 months (m).
Andrews MD, David W., Bar-Ad, Voichita, Bhamidipati, Deepak, Blomain, Erik S, Dan, Tu, Evans, James J., Farrell, MD, Christopher J, Glass, MD, Jon, Judy, MD, Kevin, Kim, Lyndon, Palmer, Joshua, Shi, Wenyin, Siglin, Joshua, Wang, Yang, Werner-Wasik, Maria   +14 more
core   +2 more sources

Inhibition of KIF14 Suppresses Tumor Cell Growth and Promotes Apoptosis in Human Glioblastoma

Cellular Physiology and Biochemistry, 2015
Background/Aims: The mitotic kinesin superfamily protein KIF14 is essential for cytokinesis and chromosome segregation, and increased KIF14 expression is related to a variety of human cancers.
Wei Huang, JunYu Wang, Danfeng Zhang, Wen Chen, Lijun Hou, Xiaojun Wu, Yicheng Lu   +6 more
doaj   +1 more source

Congenital Intracranial Tumors: Prenatal Diagnosis by Fetal Magnetic Resonance Imaging

iRADIOLOGY, EarlyView.
Fetal intracranial tumors are rare, comprising 0.5%–1.9% of all childhood tumors, with their true incidence potentially underestimated. This review highlights the role of fetal MRI, particularly with advanced sequences, in diagnosing common fetal brain tumors such as teratomas, astrocytomas, and choroid plexus papillomas, often presenting unique ...
Jing‐Ya Ren, Hui Ji, Ming Zhu, Su‐Zhen Dong   +3 more
wiley   +1 more source

Activation of Egr-1 expression in astrocytes by HIV-1 Tat: new insights into astrocyte-mediated Tat neurotoxicity [PDF]

, 2011
Human immunodeficiency virus type 1 (HIV-1) Tat plays an important role in HIV-associated neuropathogenesis; the underlying mechanisms are still evolving. We have recently shown that HIV-1 Tat induces expression of glial fibrillary acidic protein (GFAP),
Fan, Yan, Green, Linden A., He, Johnny J., oh Kim, Byung, Zou, Wei   +4 more
core   +1 more source

Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma

Genome Research, 2013
Low-grade brain tumors (pilocytic astrocytomas) arising in the neurofibromatosis type 1 (NF1) inherited cancer predisposition syndrome are hypothesized to result from a combination of germline and acquired somatic NF1 tumor suppressor gene mutations ...
D. Gutmann, M. McLellan, I. Hussain, J. Wallis, L. Fulton, R. Fulton, V. Magrini, Ryan T. Demeter, T. Wylie, C. Kandoth, J. Leonard, A. Guha, Christopher A. Miller, L. Ding, E. Mardis   +14 more
semanticscholar   +1 more source