Results 61 to 70 of about 57,588 (263)

mutations in pediatric pilomyxoid astrocytoma

, 2021
Background Pilomyxoid astrocytomas are an aggressive subtype of astrocytoma, not graded by WHO, frequently located in hypothalamic/chiasmatic region, affecting diencephalic structures, and characterized by shorter survival and high recurrence rates ...
William Sullivan, Kristopher T. Kahle, E. Zeynep Erson‐Omay, Anita Huttner, Asher M. Marks, Benjamin C. Reeves, Elena I. Fomchenko   +6 more
core   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Glycosylated dendrimer nanoamplifiers hijack DNA damage‐immune crosstalk for enhanced dual‐track therapy of orthotopic glioblastoma

BMEMat, EarlyView.
A glycosylated dendrimer nanoamplifier hijacks DNA damage‐immune crosstalk for enhanced radio‐immunotherapy of glioblastoma. The responsive release of demethylcantharidin simultaneously blocks repair‐mediated resistance by inhibiting DNA repair and overcomes adaptive immune resistance.
Cong Song, Binghan Liu, Junjie Liu, Ce Li, Wenqing Man, Xurui Sun, Chang Yuan, Yanjun Wang, Hong Pan, Shuanglian Wang, Zhiming Zheng   +10 more
wiley   +1 more source

Astrocytoma WHO grade III.

, 2016
20-year old woman with left frontal tumor with FLAIR- hyperintensity (A) and minimal contrast enhancement (B); leading to a diagnosis of an astrocytoma WHO grade III by MRI alone.
Lino Morris Sawicki (3166911), Ina Binse (3372986), Cornelius Deuschl (693006), Marc Schlamann (631484), Thorsten Poeppel (3372974), Johannes Grueneisen (560821), Joerg Hense (3372989), Sophia Goericke (3372977), Michael Forsting (382317), Nicolai El Hindy (3372992), Harald Quick (3372980), Karsten Wrede (3372983), Lale Umutlu (505989), Juliane Goebel (2806798)   +13 more
core   +1 more source

Localizing value of cutaneous ictal phenomena: A systematic review

Epileptic Disorders, EarlyView.
Abstract Objective Clinical observation of autonomic signs during seizures can aid in localizing the epileptogenic zone (EZ). We performed a systematic review and meta‐analysis to evaluate the localizing value of ictal cutaneous phenomena—piloerection, sweating, pallor, and flushing—in focal epilepsy and their relevance to presurgical evaluation ...
R. Rocamora, L. Vilella, L. Panadés‐De Oliveira, F. Álvarez‐Gómez, T. Ibáñez, A. Celdrán, G. Zimmermann, R. Zucca   +7 more
wiley   +1 more source

Importance of GFAP isoform-specific analyses in astrocytoma [PDF]

, 2019
Gliomas are a heterogenous group of malignant primary brain tumors that arise from glia cells or their progenitors and rely on accurate diagnosis for prognosis and treatment strategies. Although recent developments in the molecular biology of glioma have
van Bodegraven, Emma J., Jessy V. van Asperen, Hol, Elly M., Elly M. Hol, Robe, Pierre A J, van Bodegraven, Emma J, Pierre A.J. Robe, van Asperen, Jessy V., Emma J. van Bodegraven, Robe, Pierre A.J., van Asperen, Jessy V, Hol, Elly M   +11 more
core   +1 more source

Genetic testing among patients evaluated for epilepsy surgery

Epileptic Disorders, EarlyView.
Abstract Objective Genetic testing performed to identify the underlying etiology of epilepsy has become increasingly common and is now being recommended as part of the presurgical evaluation for epilepsy surgery. This study aimed to characterize the types of genetic tests performed in patients evaluated for epilepsy surgery and assess how genetic ...
Anni Saarela, Veera‐Julia Kuronen, Oskari Timonen, Leena Jutila, Katri Silvennoinen, Annemari Kilpeläinen, Jarkko Kirjavainen, Reetta Kälviäinen   +7 more
wiley   +1 more source

Immunoexpression of Nestin and Ki-67 in Astrocytoma in a Single Tertiary Health Care Centre

JLUMHS
OBJECTIVE: To evaluate the prognostic significance of Nestin and Ki-67 expression in Astrocytoma across different grades. METHODOLOGY: A retrospective cross-sectional analysis was conducted at the Histology Department, Basic Medical Sciences Institute ...
Prih Bashir, Noshaba Rahat, Humera Shahzad, Asma Jalbani, Farah Siraj, Zumrud Momin   +5 more
doaj   +1 more source

The microRNA and messengerRNA profile of the RNA-induced silencing complex in human primary astrocyte and astrocytoma cells. [PDF]

PLoS ONE, 2010
GW/P bodies are cytoplasmic ribonucleoprotein-rich foci involved in microRNA (miRNA)-mediated messenger RNA (mRNA) silencing and degradation. The mRNA regulatory functions within GW/P bodies are mediated by GW182 and its binding partner hAgo2 that bind ...
Joanna J Moser, Marvin J Fritzler
doaj   +1 more source

Pilocytic astrocytoma of neurohypophysis

, 2003
A case of pilocytic astrocytoma of neurohypophysis is presented. The clinical, pathological and MRI features of a rare tumor of the neurohypophysis are described.
Cakir, ERTUĞRUL, KUZEYLI, KAYHAN, USUL, HAYDAR, COBANOGLU, U, REIS, AHU, SARI, A   +5 more
core   +1 more source