Neuroligin-3 R451C induces gain-of-function gene expression in astroglia in an astroglia-enriched brain organoid model [PDF]
Cell RegenerationAstroglia are integral to brain development and the emergence of neurodevelopmental disorders. However, studying the pathophysiology of human astroglia using brain organoid models has been hindered by inefficient astrogliogenesis.
Rui Dang +8 more
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Beyond the canonical niche: how astrocytes carried neurogenic potential into the brain parenchyma [PDF]
Frontiers in Cell and Developmental BiologyThe cellular and molecular programs underlying neurogenesis are deeply conserved in metazoans. In vertebrates, neural progenitor and glial lineages converged within the astroglia lineage, which can alternate between stem cell activity and homeostatic ...
Marco Fogli +9 more
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cFLIP in the molecular regulation of astroglia-driven neuroinflammation in experimental glaucoma [PDF]
Journal of NeuroinflammationBackground Recent experimental studies of neuroinflammation in glaucoma pointed to cFLIP as a molecular switch for cell fate decisions, mainly regulating cell type-specific caspase-8 functions in cell death and inflammation. This study aimed to determine
Xiangjun Yang +5 more
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Chlorogenic Acid Alleviates the Detrimental Effects of Concurrent Hyperglycemia and Chronic Stress on Brain Homeostasis by Modulating Antioxidative Defense in Adult Zebrafish [PDF]
AntioxidantsOxidative stress is a key contributor to diabetes-related cognitive decline and is intensified by diabetes distress (DD), the psychological burden of disease management.
Rhea Subba +7 more
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Potential and Realized Impact of Astroglia Ca2 + Dynamics on Circuit Function and Behavior
Frontiers in Cellular Neuroscience, 2021 Astroglia display a wide range of spontaneous and behavioral state-dependent Ca2+ dynamics. During heightened vigilance, noradrenergic signaling leads to quasi-synchronous Ca2+ elevations encompassing soma and processes across the brain-wide astroglia ...
Eunice Y. Lim +4 more
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Frontiers in Pharmacology, 2021 Synaptic alterations concomitant with neuroinflammation have been described in patients and experimental models of autism spectrum disorder (ASD). However, the role of microglia and astroglia in relation to synaptic changes is poorly understood.
Marianela Evelyn Traetta +9 more
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Neurobiology of Disease, 2021 Retinal ganglion cells (RGCs) expanding from the retina to the brain are primary victims of neurodegeneration in glaucoma, a leading cause of blindness; however, the neighboring astroglia survive the glaucoma-related stress and promote neuroinflammation.
Xiangjun Yang, Qun Zeng, Gülgün Tezel
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Interactions with Astroglia Influence the Shape of the Developing Dendritic Arbor and Restrict Dendrite Growth Independent of Promoting Synaptic Contacts. [PDF]
PLoS ONE, 2017 Astroglia play key roles in the development of neurons, ranging from regulating neuron survival to promoting synapse formation, yet basic questions remain about whether astrocytes might be involved in forming the dendritic arbor.
Ginger S Withers +4 more
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Journal of Neuroinflammation, 2021 Background Brain astroglia are activated preceding the onset of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS).
Hayato Une +10 more
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Astrocytes in human central nervous system diseases: a frontier for new therapies
Signal Transduction and Targeted Therapy, 2023 Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system (CNS). Astroglia contribute to the pathophysiology of all neurological and neuropsychiatric disorders in ways that can ...
Alexei Verkhratsky +7 more
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