Results 11 to 20 of about 11,776 (162)
Astroglia and Tau: New Perspectives [PDF]
Frontiers in Aging Neuroscience, 2020 Astrocytes contribute to the pathogenesis of neurodegenerative proteinopathies as influencing neuronal degeneration or neuroprotection, and also act as potential mediators of the propagation or elimination of disease-associated proteins.
Gabor G. Kovacs +2 more
doaj +3 more sources
Physiological Reviews, 2018 Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in morphological appearance; they express a multitude of receptors, channels, and membrane transporters.
Verkhratsky, Alexei, Nedergaard, Maiken
openaire +4 more sources
Astroglia in Autism Spectrum Disorder [PDF]
International Journal of Molecular Sciences, 2021 Autism spectrum disorder (ASD) is an umbrella term encompassing several neurodevelopmental disorders such as Asperger syndrome or autism. It is characterised by the occurrence of distinct deficits in social behaviour and communication and repetitive patterns of behaviour. The symptoms may be of different intensity and may vary in types.
Kinga Gzielo, Agnieszka Nikiforuk
openaire +2 more sources
Astroglia In Neurological Diseases [PDF]
Future Neurology, 2013 Astroglia encompass a subset of versatile glial cells that fulfill a major homeostatic role in the mammalian brain. Since any brain disease results from failure in brain homeostasis, astroglial cells are involved in many, if not all, aspects of neurological and/or psychiatric disorders.
Verkhratsky, Alexei +2 more
openaire +3 more sources
, 2019 Astrocytes are principal cells responsible for maintaining the brain homeostasis. Additionally, these glial cells are also involved in homocellular (astrocyte-astrocyte) and heterocellular (astrocyte-other cell types) signalling and metabolism. These astroglial functions require an expression of the assortment of molecules, be that transporters or ...
Verkhratsky, Alexei +3 more
openaire +4 more sources
Neuroprotective potential of astroglia [PDF]
Journal of Neuroscience Research, 2017 Astroglia are the homoeostatic cells of the central nervous system, which participate in all essential functions of the brain. Astrocytes support neuronal networks by handling water and ion fluxes, transmitter clearance, provision of antioxidants, and metabolic precursors and growth factors.
Beihui Liu +2 more
openaire +4 more sources
General Pathophysiology of Astroglia [PDF]
, 2019 Astroglial cells are involved in most if not in all pathologies of the brain. These cells can change the morpho-functional properties in response to pathology or innate changes of these cells can lead to pathologies. Overall pathological changes in astroglia are complex and diverse and often vary with different disease stages.
Verkhratsky, Alexei +4 more
openaire +6 more sources
Cells, 2021 The heteroreceptor complexes present a novel biological principle for signal integration. These complexes and their allosteric receptor–receptor interactions are bidirectional and novel targets for treatment of CNS diseases including mental diseases. The
Dasiel O. Borroto-Escuela +11 more
doaj +1 more source
Memory Formation Shaped by Astroglia [PDF]
Frontiers in Integrative Neuroscience, 2015 Astrocytes, the most heterogeneous glial cells in the central nervous system (CNS), execute a multitude of homeostatic functions and contribute to memory formation. Consolidation of synaptic and systemic memory is a prolonged process and hours are required to form long-term memory.
Robert eZorec +10 more
openaire +6 more sources
Enhanced xeno-free differentiation of hiPSC-derived astroglia applied in a blood–brain barrier model
Fluids and Barriers of the CNS, 2019 Background Human induced pluripotent stem cells (hiPSC) hold great promise for use in cell therapy applications and for improved in vitro models of human disease.
Louise Delsing +4 more
doaj +1 more source