Results 31 to 40 of about 11,776 (162)
, 2019 Leukodystrophies are genetically determined disorders affecting the white matter of the central nervous system. The combination of MRI pattern recognition and next-generation sequencing for the definition of novel disease entities has recently demonstrated that many leukodystrophies are due to the primary involvement and/or mutations in genes ...
Jorge, M. S., Bugiani, Marianna
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Roles and Regulation of Ketogenesis in Cultured Astroglia and Neurons Under Hypoxia and Hypoglycemia
ASN Neuro, 2014 Exogenous ketone bodies (KBs), acetoacetate (AA), and β-hydroxybutyrate (BHB) act as alternative energy substrates in neural cells under starvation. The present study examined the endogenous ketogenic capacity of astroglia under hypoxia with/without ...
Shinichi Takahashi +4 more
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ASN Neuro, 2018 Oxidative stress plays an important role in the onset and progression of Parkinson disease. Although released dopamine at the synaptic terminal is mostly reabsorbed by dopaminergic neurons, some dopamine is presumably taken up by astroglia.
Kyoko Mashima +9 more
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Astroglia in Alzheimer’s Disease [PDF]
, 2019 Alzheimer's disease is the most common cause of dementia. Cellular changes in the brains of the patients suffering from Alzheimer's disease occur well in advance of the clinical symptoms. At the cellular level, the most dramatic is a demise of neurones. As astroglial cells carry out homeostatic functions of the brain, it is certain that these cells are
Verkhratsky, Alexei +3 more
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Redox Biology, 2017 Astrogliosis has long been recognized in Parkinson's disease (PD), the most common neurodegenerative movement disorder. However, the mechanisms of how astroglia become activated remain unclear. Reciprocal interactions between microglia and astroglia play
Liyan Hou +10 more
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Ageing & Longevity, 2021 Astroglia are neural cells of ectodermal, neuroepithelial origin responsible for homoeostasis and defence of the central nervous system (CNS). Ageing reduces the functional capacity of all organs, so does that of the nervous system, the latter is evident in the reduction of cognitive abilities, learning and memory.
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Neurobiology of Disease, 2019 The neuropathogenesis of HIV associated neurocognitive disorders (HAND) involves disruption of mitochondrial homeostasis and increased neuroinflammation.
Mary K. Swinton +14 more
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The Roles of Lpar1 in Central Nervous System Disorders and Diseases
Frontiers in Neuroscience, 2021 Lysophosphatidic acid receptor 1 (Lpar1), which is found in almost all human tissues but is most abundant in the brain, can couple to G protein-coupled receptors (GPCRs) and participate in regulating cell proliferation, migration, survival, and apoptosis.
Dongqiong Xiao +5 more
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Frontiers in Cellular Neuroscience, 2014 In the brain, astrocytes represent the cellular population that expresses the highest amount of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap junction channels and hemichannels that provide pathways for direct ...
Veronica eAbudara +8 more
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Frontiers in Physiology, 2019 Bestrophin-3, a potential candidate for a calcium-activated chloride channel, recently was suggested to have cell-protective functions. We studied the expression and alternative splicing of bestrophin-3 in neonatal mouse brain and after hypoxic-ischemic (
Veronika Golubinskaya +6 more
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