Results 51 to 60 of about 11,776 (162)
Frontiers in Cellular Neuroscience, 2022 Astrocytes play key roles in supporting the central nervous system structure, regulating synaptic functions, and maintaining brain homeostasis. The number of astrocytes in the cerebrum has markedly increased through evolution.
Jureepon Roboon +13 more
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Brain Pathology, EarlyView.14‐3‐3 protein homeostasis is disrupted in Lewy body pathology, showing a diminution of six isotypes and overexpression of stratifin. The latter was associated with stratifin colocalization with tau pathology and reactive astrocytes. Platelets, as a peripheral biomarker source, mirrored inversely cortical 14‐3‐3 gene expression patterns in dementia ...
Laura Marsal‐García +13 more
wiley +1 more source
Ionic signalling in astroglia beyond calcium [PDF]
The Journal of Physiology, 2019 AbstractAstrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations, as well as assisting and modulating synaptic transmission by uptake and catabolism of ...
Alexei Verkhratsky +2 more
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Toxins, 2018 Neuropathic pain represents a significant clinical problem because it is a chronic condition often refractory to available therapy. Therefore, there is still a strong need for new analgesics.
Ewelina Rojewska +3 more
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Astrocyte Heterogeneity in Regulation of Synaptic Activity
Cells, 2022 Our awareness of the number of synapse regulatory functions performed by astroglia is rapidly expanding, raising interesting questions regarding astrocyte heterogeneity and specialization across brain regions.
Anna Kruyer
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Noradrenergic Hypothesis Linking Neurodegeneration-Based Cognitive Decline and Astroglia
Frontiers in Molecular Neuroscience, 2018 In the past, manipulation of the cholinergic system was seen as the most likely therapeutic for neurodegeneration-based cognitive decline in Alzheimer's disease (AD) (Whitehouse et al., 1982).
Giampiero Leanza +3 more
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Type 1 Interleukin-4 Signaling Obliterates Mouse Astroglia in vivo but Not in vitro
Frontiers in Cell and Developmental Biology, 2020 Recent findings suggest that reduced neurogenesis could be one of the underlying reasons for the exacerbated neuropathology in humans, thus restoring the neural stem cell proliferation and neurogenesis could help to circumvent some pathological aspects ...
Violeta Mashkaryan +12 more
doaj +1 more source
Brain Pathology, EarlyView.Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari +10 more
wiley +1 more source
Prefrontal Cortex Astroglia Modulate Anhedonia-like Behavior
Molecular Psychiatry, 2023 AbstractReductions of astroglia expressing glial fibrillary acidic protein (GFAP) are consistently found in the prefrontal cortex (PFC) of patients with depression and in rodent chronic stress models. Here, we examine the consequences of PFC GFAP+ cell depletion and cell activity enhancement on depressive-like behaviors in rodents.
S. A. Codeluppi +14 more
openaire +3 more sources
Sleep Disturbance in Bipolar Disorder: Neuroglia and Circadian Rhythms
Frontiers in Psychiatry, 2019 The worldwide prevalence of sleep disorders is approximately 50%, with an even higher occurrence in a psychiatric population. Bipolar disorder (BD) is a severe mental illness characterized by shifts in mood and activity.
Luca Steardo +6 more
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