Results 281 to 290 of about 848,132 (406)

Asymmetric Synthesis of Highly Substituted Spiro[2H‐pyrrole‐2,3‐Succinimide] Derivatives by Copper‐Catalyzed Post‐Ugi Reactions

Advanced Synthesis &Catalysis, EarlyView.
Abstract Herein we present a novel one‐pot methodology for the synthesis of enantioenriched 2H‐pyrrolespirosuccinimides by copper‐catalyzed reactions on Ugi adducts derived from enantiopure α‐alkylbenzyl amines through a chirality transfer process. We have proposed a mechanism, supported by density functional theory (DFT) calculations, where a hydrogen
Javier Gómez‐Ayuso, Israel Carreira‐Barral, Roberto Quesada, María García‐Valverde   +3 more
wiley   +1 more source

Consecutive chirality transfer: efficient synthesis of chiral C,O-chelated BINOL/gold(iii) complexes for asymmetric catalysis and chiral resolution of disubstituted BINOLs. [PDF]

Chem Sci
Chan KA, O WY, Jiang JJ, Cui JF, Wong MK.   +4 more
europepmc   +1 more source

A Study of Structure and Dynamics of Prochiral N-C Axis for Asymmetric Tran- sition Metal Catalysis, with Phospho- rous-31 (V) by 3D NMR Spectroscopy Combined with MO Calculation

, 2004
Yohko Sakamoto, Kazuhiro Kondo, Maiko Tokunaga, Kumiko Kazuta, Hiroko Fujita, Yasuoki Murakami, Toyohiko Aoyama   +6 more
openalex   +1 more source

Photochemical Preparation of (Aza−)Indolines: Diastereoselective Synthesis and Polarity Reversal Strategy

Advanced Synthesis &Catalysis, EarlyView.
Abstract Herein, we present the first light‐mediated, diastereoselective de novo synthesis for 2,3‐substituted indolines, a privileged scaffold in pharmaceuticals. The protocol was tested with various aryl and alkyl groups, maintaining high yields up to 85% across different substituents.
Julian J. Melder, Maxi L. Heldner, Julia Svetličić, Abdinasir Adow, Frank Rominger, Matthias Rudolph, Günter Helmchen, A. Stephen K. Hashmi   +7 more
wiley   +1 more source

Scaffold-Oriented Asymmetric Catalysis: Conformational Modulation of Transition State Multivalency during a Catalyst-Controlled Assembly of a Pharmaceutically Relevant Atropisomer. [PDF]

Chemistry
Tampellini N, Mercado BQ, Miller SJ.
europepmc   +1 more source

Self‐Assembly of Bidentate Ligands for Combinatorial Homogeneous Catalysis: Asymmetric Rhodium‐Catalyzed Hydrogenation. [PDF]

, 2006
Martine Weis, Christoph Waloch, Wolfgang Seiche, Bernhard Breit   +3 more
openalex   +1 more source

Dearomative, Intramolecular Bromoetherification of Carbohydrate‐derived Glycosyl Furans: Access to Enantiopure 6‐Bromo‐Furo[3,2‐b]furans

Advanced Synthesis &Catalysis, EarlyView.
Abstract Glycosyl furans represent versatile chiral platform molecules that can be readily accessed via the Garcia Gonzalez reaction. Herein, we report a dearomative, intramolecular bromoetherification of carbohydrate‐derived glycosyl furans to generate enantiopure 6‐bromo‐furo[3,2‐b]furans in up to 69% yield. The method employs N‐Br aromatic amides as
William J. Berkey, Lindsey R. C. Bryson, Russell Kirkland, Kaitlyn S. Otte, Christopher W. Jones, Stefan France   +5 more
wiley   +1 more source

Asymmetric Catalysis upon Helically Chiral Loratadine Analogues Unveils Enantiomer-Dependent Antihistamine Activity. [PDF]

J Am Chem Soc, 2020
Stone EA, Cutrona KJ, Miller SJ.
europepmc   +1 more source

Methodologies in Asymmetric Catalysis

, 2004
Sanjay V. Malhotra
openalex   +1 more source

Resolution of Racemic 2‐Aminocyclohexanol Derivatives and Their Application as Ligands in Asymmetric Catalysis. [PDF]

, 2006
Ingo Schiffers, Toni Rantanen, Frank Schmidt, Werner Bergmans, Lorenzo Zani, Carsten Bolm   +5 more
openalex   +1 more source