Results 91 to 100 of about 492,930 (297)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

PRICE ASYMMETRY IN SPATIAL FED CATTLE MARKETS [PDF]

Price asymmetry in spatial fed cattle markets is investigated for three large markets (Texas Panhandle, Nebraska, and Colorado) and one small market (Utah).
Bailey, DeeVon, Brorsen, B. Wade
core  

Development of the positive-negative asymmetry effect: In-group exclusion norm as a mediator of children’s evaluations on negative attributes. [PDF]

, 2007
Two studies were conducted that go beyond previous research by examining when and why children might show intergroup bias in the attribution of positive, but not negative traits (PNAE: the positive-negative asymmetry effect, Mummendey & Otten, 1998).
Brown, Rupert, Ahmavaara, Annie, Samson, Jenni, Katie Arnold (16057166), Ahmavaara, Anni M., Rutland, Adam, Lindsey Cameron (7537682), Arnold, Katie, Cameron, Lindsey, Adam Rutland (9160025), Anni Ahmavaara (16057163), Rupert Brown (4461505), Jenni Samson (16057169)   +12 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

EEG-based major depressive disorder recognition by neural oscillation and asymmetry

Frontiers in Neuroscience
BackgroundMajor Depressive Disorder (MDD) is a pervasive mental health issue with significant diagnostic challenges. Electroencephalography (EEG) offers a non-invasive window into the neural dynamics associated with MDD, yet the diagnostic efficacy is ...
Xinyu Liu, Xinyu Liu, Haoran Zhang, Haoran Zhang, Yi Cui, Tong Zhao, Bin Wang, Bin Wang, Xiaomeng Xie, Xiaomeng Xie, Sixiang Liang, Sixiang Liang, Sha Sha, Sha Sha, Yuxiang Yan, Xixi Zhao, Xixi Zhao, Ling Zhang, Ling Zhang   +18 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

XBRL Adoption of Information Asymmetry in Manufacturing Company [PDF]

, 2021
Manufacturing companies in the textile and garment sub-sector are the largest contributors to Indonesia’s GDP, the industry has experienced a decline in performance due to the COVID-19 pandemic which resulted in a negative GDP in 2020, companies must ...
Kurniasari, Florentina, Prihanto, Johny Natu, Muthalia, Muthalia   +2 more
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