Results 81 to 90 of about 492,930 (297)

Common variants in left/right asymmetry genes and pathways are associated with relative hand skill [PDF]

, 2013
This work was supported by the University of St Andrews, the UK Medical Research Council (grant number G0800523/86473 to SP), the Max Plank Society, and the the EU (Neurodys, 018696).
Timpson, NJ, David M. Evans (152874), Nicholas J Timpson, Webber, Caleb, St Pourcain, B., Evans, D.M., Morris, Andrew P, Talcott, J., Scerri, TS, Joel B Talcott, Simon E Fisher, Simon E. Fisher (214896), Talcott, JB, Stein, J., Ring, SM, Stein, J, Kemp, John P, Silvia Paracchini, Smith, George Davey, Thomas S Scerri, St Pourcain, B, Brandler, WM, Ring, S.M., Andrew P Morris, Anthony P. Monaco (184852), Monaco, Anthony P., Beate St Pourcain, Evans, D., John Stein, Kemp, J.P., Talcott, Joel B., Davey Smith, George, Brandler, William M., Fisher, S.E., Talcott, J.B., Susan M Ring, Timpson, N., Kemp, John, Fisher, Simon, Evans, DM, Timpson, Nicholas J, Paracchini, S, Caleb Webber (42885), David M Evans, Monaco, A.P., Nicholas J. Timpson (111625), Brandler, William M, Davey Smith, G., Evans, David, Paracchini, S., Morris, Andrew P., Monaco, Anthony P, Morris, A., Smith, GD, St Pourcain, Beate, Ring, Susan, George Davey Smith (82619), Smith, G.D., Andrew P. Morris (145709), Pourcain, B. St, Timpson, Nicholas, Caleb Webber, Susan M. Ring (116089), Monaco, AP, William M. Brandler (458144), Brandler, William, Scerri, Thomas, Scerri, T.S., Anthony P Monaco, Webber, C, John P Kemp, Stein, John, Brandler, W.M., Kemp, J., Evans, David M, Timpson, Nicholas J., Monaco, A., Paracchini, Silvia, Kemp, John P., Thomas S. Scerri (238616), Ring, Susan M., Scerri, Thomas S, Smith, George D., John Stein (238626), Morris, A.P., William M Brandler, Talcott, Joel B, Monaco, Anthony, Morris, Andrew, Evans, David M., Brandler, W., Talcott, Joel, John P. Kemp (152856), Fisher, Simon E, Ring, Susan M, Kemp, JP, Fisher, S., Beate St Pourcain (116086), Fisher, SE, Webber, C., Joel B. Talcott (297005), Scerri, T., Morris, AP, Silvia Paracchini (238619), Timpson, N.J., George Davey Smith, Fisher, Simon E., Ring, S., Scerri, Thomas S.   +108 more
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IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hemispheric Asymmetry of White Matter Hyperintensity in Association With Lacunar Infarction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background White matter hyperintensities (WMHs) are commonly asymmetric between hemispheres but for unknown reasons. We investigated asymmetric WMHs associated with lacunar infarcts.
Wi‐Sun Ryu, Dawid Schellingerhout, Hee‐Seung Ahn, Soo‐Hyun Park, Keun‐Sik Hong, Sang‐Wuk Jeong, Man‐Seok Park, Kang‐Ho Choi, Joon‐Tae Kim, Beom Joon Kim, Moon‐Ku Han, Jun Lee, Jae‐Kwan Cha, Dae‐Hyun Kim, Hyun‐Wook Nah, Soo Joo Lee, Yong‐Jin Cho, Byung‐Chul Lee, Kyung‐Ho Yu, Mi‐Sun Oh, Jong‐Moo Park, Kyusik Kang, Kyung Bok Lee, Tai‐Hwan Park, Sang‐Soon Park, Eric E. Smith, Juneyoung Lee, Hee‐Joon Bae, Dong‐Eog Kim   +28 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Model Membrane Systems Used to Study Plasma Membrane Lipid Asymmetry

, 2021
It is well known that the lipid distribution in the bilayer leaflets of mammalian plasma membranes (PMs) is not symmetric. Despite this, model membrane studies have largely relied on chemically symmetric model membranes for the study of lipid–lipid and ...
Heberle, Frederick A., Enoki, Thais A., Milka Doktorova, Doktorova, Milka, Jacob J. Kinnun, Kinnun, Jacob J., Kennison, Kristen B., Katsaras, John, Thais A. Enoki, Frederick A. Heberle, Haden L. Scott, Kristen B. Kennison, John Katsaras, Scott, Haden L.   +13 more
core   +1 more source

Asymmetry in antlers of barren-ground caribou, Northwest Territories, Canada

Rangifer, 1986
Pairs of antlers were obtained from 287 barren-ground caribou (Rangifer tarandus groenlandicus) of the Kaminuriak herd in the Northwest Territories, Canada.
Frank L. Miller
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The relationship between Hippocampal asymmetry and working memory processing in combat-related PTSD: a monozygotic twin study [PDF]

, 2012
BACKGROUND: PTSD is associated with reduction in hippocampal volume and abnormalities in hippocampal function. Hippocampal asymmetry has received less attention, but potentially could indicate lateralised differences in vulnerability to trauma.
McFarlane, Alexander, Veltmeyer, Melinda, Hall, T., Metzger, L., Melinda Veltmeyer, Gilbertson, Mark, Orr, Scott, Gilbertson, M., Linda J Metzger, Galletly, C., Roger K Pitman, Pitman, Roger, Cherrie Galletly, Clark, C Richard, Veltmeyer, M., Orr, S., Clark, C., Alexander McFarlane, McFarlane, A., C Clark, Pitman, R., Timothy Hall, Hall, Timothy, Scott P Orr, Metzger, Linda J, Mark W Gilbertson, Galletly, Cherrie   +26 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Information Asymmetry Its Roles and Effects on Hotel Management

, 2014
The aim of this thesis work was to review the available literature about information asymmetry, by concentrating especially on its effects on hotel management and testing it practically.
Pilosyan, Armine
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