Results 81 to 90 of about 22,695 (254)
Advanced Science, EarlyView.IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia +8 more
wiley +1 more source
A Double Error Dynamic Asymptote Model of Associative Learning
, 2017 In this paper a formal model of associative learning is presented which incorporates representational and computational mechanisms that, as a coherent corpus, empower it to make accurate predictions of a wide variety of phenomena that so far have eluded ...
Niklas H. Kokkola +2 more
core +1 more source
Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
, 2018 The symbols are the maximum-likelihood estimates and the bars are the 95% confidence intervals for the estimated survival rate at asymptote. Lines indicate the survival asymptote estimates for each respective treatment based on the original data.
Pedro Monteiro (13785) +11 more
core +1 more source
Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content
Advanced Science, EarlyView.Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri +3 more
wiley +1 more source
Brain Network Dynamics of Local and Global Predictive Processing in Aging
Advanced Science, EarlyView.Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen +9 more
wiley +1 more source
Advanced Science, EarlyView.Planar ferroelectric lattices with rationally‐tailored topology and polarization achieve programmable piezoelectric and pyroelectric properties. Analytical modeling, homogenization, and experiments collectively demonstrate enhanced and tunable longitudinal, transverse, and shear piezoelectric responses, together with substantially improved ...
Jiahao Shi +6 more
wiley +1 more source
The Asymptote of Consciousness and the Law of the Quarter
In this paper, the author builds on his previous findings, examining the systemic nature and patterns of life's development to its highest level of organization, namely, the level of developed consciousness. He demonstrated its systemic insufficiency for
Valeriy Revo
core +1 more source
Advanced Science, EarlyView.Across scientific, technological, commercial, and pharmacological domains, individuals and organizations disengage from a previously adopted practice not at random, but as their network neighbors detach. The probability of detachment rises with the number of neighbors who have already disengaged. Preferential detachment reshapes network disintegration,
Binglu Wang +5 more
wiley +1 more source
BMC Genetics, 2011 Background Turkey is an important agricultural species and is largely used as a meat bird. In 2004, turkey represented 6.5% of the world poultry meat production. The world-wide turkey population has rapidly grown due to increased commercial farming.
Ducro Bart J +5 more
doaj +1 more source