Results 71 to 80 of about 6,177,620 (296)

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia   +8 more
wiley   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

open access: yesAdvanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English   +9 more
wiley   +1 more source

Hacking the Colebrook-White equation: The Tolentino-𝒁 method via algebraic collapse and its bit-to-bit equivalence in 64-bit architectures [PDF]

open access: yesINCAS Bulletin
The resolution of the Colebrook-White equation has historically been a stability challenge in Computational Fluid Dynamics (CFD) due to its transcendental and implicit nature.
San L. TOLENTINO
doaj   +1 more source

Discovering asymptotic expansions for problems in mechanics using symbolic regression [PDF]

open access: yes
Recently, symbolic regression (SR) has demonstrated its efficiency for discovering basic governing relations in physical systems. A major impact can be potentially achieved by coupling symbolic regression with asymptotic methodology.
Abdusalamov, Rasul   +2 more
core   +1 more source

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

open access: yesAdvanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri   +3 more
wiley   +1 more source

Relative efficiency of Argentinean airports [PDF]

open access: yes
The main objectives of this paper are to measure the relative efficiency of Argentinean airports, and to infer possible regulatory consequences of the results. We pay attention to regional differences that could help the regulator in its task.
Fabián Garitta   +2 more
core  

Low‐Power Control Of Resistance Switching Transitions in First‐Order Memristors

open access: yesAdvanced Electronic Materials, EarlyView.
Joule losses are a serious concern in modern integrated circuit design. In this regard, minimizing the energy necessary for programming memristors should be handled with care. This manuscript presents an optimal control framework, allowing to derive energy‐efficient programming voltage protocols for resistance switching devices. Following this approach,
Valeriy A. Slipko   +3 more
wiley   +1 more source

Energy Efficiency Board 2020 programs and operations report.

open access: yes, 2021
Annual; Began with 2010; ceased with 2011.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
core   +1 more source

Nonlinear Dynamics and Invariants of Motion in ReRAM Cells

open access: yesAdvanced Electronic Materials, EarlyView.
A second‐order cell, hosting one capacitor and two back‐to‐back ReRAMs, admits Invariants of Motion: its states lie on one‐dimensional manifolds at all times. The cell shows quiescent monostability or bistability, depending on the manifold index. At equilibrium, the capacitor voltage vanishes.
Mauro Di Marco   +5 more
wiley   +1 more source

National Action Plan for Energy Efficiency, Chapter 6: Energy Efficiency Program Best Practices

open access: yes, 2006
Chapter from the National Action Plan for Energy Efficiency documenting key findings from energy efficiency programs that have been successfully operating for many ...
National Action Plan for Energy Efficiency (U.S.)
core  

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