Cancer Science, Volume 117, Issue 2, Page 297-307, February 2026.R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki +3 more
wiley +1 more source
Role of N-terminal domains of p400 ATPase in the ATM interaction and DNA damage response : a thesis presented in partial fulfillment of the requirements for a the degree of Master of Science (MSc) in Genetics at Massey University, Manawatū, New Zealand [PDF]
, 2016 Efficient repair of damaged DNA and preservation of genomic integrity is integral in the maintenance of proper cellular function and prevention of unrestricted cell proliferation. One critical threat to the stability of the genome is the double strand
Weber, Lauren Elizabeth
core
Cell Proliferation, Volume 59, Issue 2, February 2026.Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao +8 more
wiley +1 more source
Formaldehyde initiates memory and motor impairments under weightlessness condition
npj MicrogravityDuring space flight, prolonged weightlessness stress exerts a range of detrimental impacts on the physiology and psychology of astronauts. These manifestations encompass depressive symptoms, anxiety, and impairments in both short-term memory and motor ...
Tianhao Mei +8 more
doaj +1 more source
Supplementary Figure 3 from DNA Protein Kinase–Dependent G<sub>2</sub> Checkpoint Revealed following Knockdown of Ataxia-Telangiectasia Mutated in Human Mammary Epithelial Cells [PDF]
, 2023 Sonnet J.H. Arlander +3 more
openalex +1 more source
Inflammation targets specific organs for cancer in carriers of BRCA1/2 pathway mutations [PDF]
, 2010 Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast/ovarian cancer that are so high and apparently so selective that many mutation carriers choose to have the most likely targets for cancer surgically removed.
Bernard Friedenson
core +1 more source
Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites [PDF]
, 2017 Background: Ataxia-telangiectasia is a pleiotropic autosomal recessive disorder caused by mutations in the ATM gene. In addition to a profound cancer predisposition, another hallmark of ataxia-telangiectasia is radiosensitivity.
Fedier, A. +5 more
core
Association of Tumor Protein p53 and Ataxia-Telangiectasia Mutated Comutation With Response to Immune Checkpoint Inhibitors and Mortality in Patients With Non–Small Cell Lung Cancer [PDF]
, 2019 Yu Chen +16 more
openalex +1 more source
Telomere protein complexes and their role in lymphoid malignancies [PDF]
, 2017 Telomeres are highly regulated and dynamic complexes that protect the genomic DNA and prevent the end of linear chromosomes from being misrecognized as a broken DNA.
Dos Santos, Patricia Carolina +2 more
core
New Views of the DNA Repair Protein Ataxia–Telangiectasia Mutated in Central Neurons: Contribution in Synaptic Dysfunctions of Neurodevelopmental and Neurodegenerative Diseases [PDF]
, 2023 Sabrina Briguglio +6 more
openalex +1 more source