Results 141 to 150 of about 41,016 (281)

Defect in Multiple Cell Cycle Checkpoints in Ataxia-Telangiectasia Postirradiation*

Journal of Biological Chemistry, 1996
The recent description of a novel gene (ATM) mutated in ataxia-telangiectasia (A-T), with homologies to genes encoding proteins involved in both G1/S and G2/M checkpoint control, points to a common defect in cell cycle control in A-T operating through ...
H. Beamish, Richard Williams, Philip C. Chen, M. Lavin   +3 more
semanticscholar   +1 more source

Chromium (VI) Activates Ataxia Telangiectasia Mutated (ATM) Protein [PDF]

Journal of Biological Chemistry, 2003
Linan Ha, Susan Ceryak, Steven R. Patierno   +2 more
openaire   +1 more source

Loss of ATM kinase activity leads to embryonic lethality in mice [PDF]

, 2012
Ataxia telangiectasia (A-T) mutated (ATM) is a key deoxyribonucleic acid (DNA) damage signaling kinase that regulates DNA repair, cell cycle checkpoints, and apoptosis.
Adams, André Nussenzweig, Baeck-Seung Lee, Bakkenist, Banin, Barlow, Barone, Barry P. Sleckman, Beli, Bensimon, Bouwman, Bredemeyer, Brown, Bryant, Buis, Bunting, Bunting, Callén, Callén, Canman, Cao, Cuadrado, Daniel, Darius Filsuf, Davis, Demuth, Difilippantonio, Difilippantonio, Difilippantonio, Dimitrova, Elson, Gapud, Gilad, Gladdy, Gurley, Hickson, Huber, Jacquemin, Jazayeri, Jeremy A. Daniel, Kennedy, Kozlov, Kozlov, Lakin, Lavin, Lee, Li, Lionel Feigenbaum, Lumsden, López-Contreras, Manuela Pellegrini, Matsuoka, McCabe, Micol, Myers, Ménisser-de Murcia, Natalya V. Belkina, Nussenzweig, Okkenhaug, Olsen, Ozeri-Galai, Pan, Pellegrini, Pierce, Rainey, Reina-San-Martin, Rickert, Savitsky, Sekiguchi, Shiloh, So, Srinivas, Stavnezer, Stracker, Tanya T. Paull, Taylor, Uziel, Ward, White, Williams, Xie, Xu, Yang, You, You, Zha, Zhang, Zhi Guo, Zhongsheng You   +88 more
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, Volume 16, Issue 5, Page 821-836, May 2026.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Poly(ADP-Ribosyl)ation affects stabilization of CHE-1 protein in response to DNA damage [PDF]

, 2011
Post-translation modifications play a crucial role in coordinating the cellular response to DNA damage. Double strand DNA breaks (DSBs) trigger the activation of ATM and Chk2 kinases, which represent the primary transducers in the signalling cascade ...
BACALINI, MARIA GIULIA
core  

The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress [PDF]

, 2015
The MRE11/RAD50/NBS1 (MRN) complex is a major sensor of DNA double strand breaks, whose role in controlling faithful DNA replication and preventing replication stress is also emerging. Inactivation of the MRN complex invariably leads to developmental and/
A Dupre, A Gulino, A Kuzyk, A Shibata, A Soriani, A Wey, A Wey, AM Duursma, AM Taylor, B Argenti, B Ricci, B Shiotani, BR Stanton, C Bruhn, C Heil, CJ Thiele, CL Marcelis, D Dominguez-Sola, D Fruci, DW Felsher, EA Rahal, F Sardina, G Giannini, G Giannini, H van Bokhoven, HE Bryant, I Screpanti, J Buis, J Charron, J Lafrance-Vanasse, J Wu, K Schlacher, K Trenz, KA Cole, KH Chrzanowska, KK To, L Di Marcotullio, LJ Valentijn, M Cognet, M Murga, M Petroni, M Petroni, M Sahún-Roncero, M Wilda, M Wojewodzka, O Chayka, P Khongkow, PE Neiman, PJ Hurlin, PO Frappart, PS Knoepfler, R Moser, R Thompson, R Waltes, RS Williams, RV Pusapati, S Albini, S Biton, S Ray, S Rohban, S Sawai, S Ying, SV Srinivasan, TG Oliver, TH Stracker, V Colicchia, V Veschi, V Veschi, W Lutz, YC Chiang, YL Lin   +70 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, Volume 16, Issue 5, Page 857-869, May 2026.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Modeling the role of p53 pulses in DNA damage- induced cell death decision

BMC Bioinformatics, 2009
Background The tumor suppressor p53 plays pivotal roles in tumorigenesis suppression. Although oscillations of p53 have been extensively studied, the mechanism of p53 pulses and their physiological roles in DNA damage response remain unclear.
Cui Jun, Zhang Shuai, Wu Yuanyuan, Chen Chun, Sun Tingzhe, Shen Pingping   +5 more
doaj   +1 more source

Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage. [PDF]

, 2007
A defective response to DNA damage is observed in several human autosomal recessive ataxias with oculomotor apraxia, including ataxia-telangiectasia. We report that senataxin, defective in ataxia oculomotor apraxia (AOA) type 2, is a nuclear protein ...
BECHEREL OJ, CHEN P, CHESSA L, CRISCUOLO C, EPE B, FILLA, ALESSANDRO, FUSSER M, GATEI M, GUEVEN N, LAVIN MF, NAKAMURA J, RUNDLE N, SURAWEERA A, WOODS R   +13 more
core  

Homoisoflavonoids—From Natural Specificity and Biosynthesis to Precision Health‐Promoting Mechanisms

Food Frontiers, Volume 7, Issue 3, May 2026.
Homoisoflavonoids are rare flavonoids with a unique bi‐aromatic oxygen‐heterocyclic structure. This review synthesizes their structure–activity relationships in anti‐inflammatory, hypoglycemic, and anticancer contexts. By highlighting their specific natural distribution and outlining biosynthetic pathways, it provides a conceptual framework and ...
Jing Zhang, Han Chen, Jinping Si, Zhigang Han, Xinfeng Zhang   +4 more
wiley   +1 more source