Results 131 to 140 of about 41,016 (281)

How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability [PDF]

, 2015
DNA double-strand breaks (DSBs) are a significant threat to the viability of a normal cell, since they can result in loss of genetic material if mitosis or replication is attempted in their presence.
Arana, Audebert, Bartek, Bartkova, Barton, Bell, Bentley, Bentley, Beucher, Bolderson, Bouwman, Brady, Bryant, Budman, Budman, Bunting, Callen, Ceccaldi, Cerbinskaite, Chan, Chapman, Chapman, Choudhury, Cornforth, Deckbar, Deckbar, Deckbar, Dion, Dohrn, Ensminger, Erkko, Falck, Fan, Farmer, Fernandez-Capetillo, Fox, Fradet-Turcotte, Garcia, Gaymes, Gerhold, Geuting, Ghezraoui, Goodarzi, Helmink, Hu, Huertas, Jacot, Jasin, Jeggo, Jeggo, Jiang, Johnson, Kakarougkas, Kakarougkas, Kakarougkas, Kastan, Kemp, Kuhne, Li, Liang, Lieber, Lobrich, Loeb, Loucas, Maacke, Markus Löbrich, Mateos-Gomez, Michailidou, Muvarak, Neubauer, Panier, Panier, Penny A. Jeggo, Plisiecka-Halasa, Povirk, Prakash, Qiao, Radhakrishnan, Rahman, Riballo, Richardson, Roth, Sallmyr, Sarbajna, Seeber, Shanbhag, Shibata, Shibata, Shibata, Simsek, Soni, Steinel, Stephan, Syeda, Symington, Takenaka, Tepsuporn, Tobin, Tobin, Uziel, Wang, Wang, Ward, Waters, Waters, Williams, Woodbine, Woodbine, Yun, Zelensky, Zimmermann   +110 more
core   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

Endoplasmic Reticulum Stress and Unfolded Protein Response in Atm-Deficient Thymocytes and Thymic Lymphoma Cells Are Attributable to Oxidative Stress

Neoplasia: An International Journal for Oncology Research, 2008
Both oxidative stress and endoplasmic reticulum (ER) stress have been implicated in carcinogenesis. It is well documented that cells deficient in the ataxia-telangiectasia mutated (ATM) gene undergo oxidative stress, which is critically involved in ...
Mingshan Yan, Jianjun Shen, Maria D. Person, Xianghong Kuang, William S. Lynn, Daphne Atlas, Paul K.Y. Wong   +6 more
doaj   +1 more source

Loss of Neuronal Cell Cycle Control in Ataxia-Telangiectasia: A Unified Disease Mechanism

Journal of Neuroscience, 2005
In ataxia-telangiectasia (A-T), the loss of the ataxia-telangiectasia mutated (ATM) kinase leads to a failure of cell cycle checkpoints and DNA double-strand break detection resulting in cellular radiation sensitivity and a predisposition to cancer ...
Yan Yang, K. Herrup
semanticscholar   +1 more source

Chromatin Regulation of DNA Damage Repair and Genome Integrity in the Central Nervous System [PDF]

, 2017
With the continued extension of lifespan, aging and age-related diseases have become a major medical challenge to our society. Aging is accompanied by changes in multiple systems. Among these, the aging process in the central nervous system is critically
Pan, Ling, Penney, Jay, Tsai, Li-Huei
core   +1 more source

The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objectives Oral dysbiosis can accelerate the progression of head and neck squamous cell carcinoma (HNSCC) by fostering a pro‐inflammatory, immunosuppressive, and metabolically altered environment. This narrative review examines the relationships between periodontitis‐associated bacteria and HNSCC, focusing on their impact on oncogenic pathways,
Yashmin Afshar, Nima Rezaei
wiley   +1 more source

A theory for the tissue specificity of BRCA1/2 related and other hereditary cancers [PDF]

, 2010
Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast and ovarian cancer that are so high and seem so selective that many mutation carriers choose to have prophylactic surgery. There has been much conjecture to explain such apparently
Bernard Friedenson
core   +1 more source

Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells [PDF]

, 2014
S-phase checkpoints are triggered in tumor cells in response to DNA replication stress caused by the tumor microenvironment or oncogenes. A recent report from our laboratory showed that tumor cells and more normal epithelial cells have a very different ...
Meuth, M.
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, Volume 20, Issue 5, Page 1364-1378, May 2026.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Thyroid hormones derivatives reduce proliferation and induce cell death and DNA damage in ovarian cancer

Scientific Reports, 2017
Ovarian cancer is a highly aggressive disease and novel treatments are required. Thyroid hormones binding to αvβ3 integrin produced growth-promoting activities in ovarian cancer and we hypothesized that natural thyroid hormone derivatives may antagonize ...
Elena Shinderman-Maman, Keren Cohen, Dotan Moskovich, Aleck Hercbergs, Haim Werner, Paul J. Davis, Martin Ellis, Osnat Ashur-Fabian   +7 more
doaj   +1 more source