Results 131 to 140 of about 1,665,599 (197)

Ataxia-telangiectasia: future prospects

, 2014
Mohammed Wajid Chaudhary, Raidah Saleem Al-Baradie Pediatric Neurology, Neurosciences Centre, King Fahad Specialist Hospital, Dammam, Kingdom of Saudi Arabia Abstract: Ataxia-telangiectasia (A-T) is an autosomal recessive multi-system disorder caused by
Al-Baradie RS, Chaudhary MW
core  

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, Volume 3, Issue 3, September 2026.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Anti-trapping scaffold protein: significance in cancer cell innate immune signaling and opportunities for immunotherapy

Frontiers in Immunology
X-ray repair cross-complementing protein 1 (XRCC1) is a scaffold protein that functions as a molecular hub, serving as a platform for the recruitment and interaction of multiple DNA repair proteins to coordinate and facilitate multistep DNA repair ...
Dawit Kidane
doaj   +1 more source

SERPINE1 (PAI‐1) Regulation in Mechanotransduction‐Associated Cellular Senescence

Journal of Cellular Biochemistry, Volume 127, Issue 9, September 2026.
ABSTRACT Cellular senescence is a complex biological process characterized by irreversible cell‐cycle arrest and acquisition of the senescence‐associated secretory phenotype (SASP). Beyond biochemical stress, increasing evidence indicates that mechanical cues from the extracellular microenvironment contribute to the regulation of senescence; however ...
Intan Chairun Nisa, Pirawan Chantachotikul, Kei Takahata, Arif Nur Muhammad Ansori, Shinji Deguchi   +4 more
wiley   +1 more source

Identification of putative ATR (Ataxia telangiectasia and Rad3 related), ATM (Ataxia telangiectasia mutated), mTOR (mechanistic Target of Rapamycin) and DNA-PKcs (DNA-dependent protein kinase, catalytic subunit) Leishmania major protein sequences.

, 2018
Identification of putative ATR (Ataxia telangiectasia and Rad3 related), ATM (Ataxia telangiectasia mutated), mTOR (mechanistic Target of Rapamycin) and DNA-PKcs (DNA-dependent protein kinase, catalytic subunit) Leishmania major protein sequences.
Raíssa Bernardes da Silva (4694260), Aldo Rogelis Aquiles Rodrigues (5802083), Carlos Renato Machado (16218), André Luiz Pedrosa (4694251)   +3 more
core   +1 more source

Chromium (VI) Activates Ataxia Telangiectasia Mutated (ATM) Protein [PDF]

Journal of Biological Chemistry, 2003
Linan Ha, Susan Ceryak, Steven R. Patierno   +2 more
openaire   +1 more source

MicroRNA‐Mediated Autophagy and Cardiovascular Diseases: Exploring the Crossroads of Atherosclerosis and Beyond

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
This graphical abstract illustrates the dynamic bidirectional crosstalk between microRNA biogenesis and autophagy, which serves as a critical regulatory axis in cardiovascular homeostasis. We highlight how specific miRNAs modulate autophagic flux to mitigate vascular inflammation and plaque instability, while concurrently, the autophagic machinery ...
Sepehr Ebrahimi‐Dehkordi, Amir Hossein Barjasteh, Aida Zarei, Sina Bazmi, Sarah Vaseghi, Sara Ashna, Amirreza Solati, Ali Yousefzadeh, Bita Safarzadeh Nasrabad, Zahra Mohammadi, Hamed Haddad Kashani, Mohammad Hossein Pourhanifeh   +11 more
wiley   +1 more source

The Health Benefits of Exercise: Molecular and Cellular Mechanisms

MedComm, Volume 7, Issue 9, September 2026.
Our synthesis integrates evidence on exercise‐induced regulatory mechanisms across multiple systems (musculoskeletal, cardiovascular, nervous, metabolic and immune), cross‐system, and aging. We also discusses adaptive regulation of exercise in extreme environments, along with the prospects and challenges of multiomics and AI‐driven precision exercise ...
Peifeng Ying, Huilin Wang, Xiu Lu, Wenjuan Zhang, Zhehao Lin, Kai Wang, Shangxuan Li, Lu Chen, Mingchao Jiang, Sarkawt Hamad, Yi Wang, Jianmin Wu, Shukuan Ling   +12 more
wiley   +1 more source

Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances

MedComm, Volume 7, Issue 9, September 2026.
The schematic outlines the key events of the abscopal effect. (Ignition) Local radiotherapy (RT) induces the release of immunogenic signals from the tumor, leading to dendritic cell (DC) activation. (Orchestration) In the tumor‐draining lymph node (TDLN), DCs prime naive T cells into cytotoxic T lymphocytes (CTLs), a process modulated by regulatory T ...
Yihong Dong, Moran Chen, Xupeng Hou, Xiaoya Tang, Xiaoli Yu, Jing Liu   +5 more
wiley   +1 more source

RP11-789C1.1 inhibits gastric cancer cell proliferation and accelerates apoptosis via the ATR/CHK1 signaling pathway

Chinese Medical Journal
. Background:. Long non-coding RNAs (lncRNAs) plays an important role in the progression of gastric cancer (GC). Their involvement ranges from genetic regulation to cancer progression.
Wenwei Liu, Wei Feng, Yongxin Zhang, Tianxiang Lei, Xiaofeng Wang, Tang Qiao, Zehong Chen, Wu Song, Ting Gao, Xiuyuan Hao   +9 more
doaj   +1 more source