Results 111 to 120 of about 41,016 (281)

Development of an Immunohistochemical Assay to Detect the Ataxia-Telangiectasia Mutated (ATM) Protein in Gastric Carcinoma

Applied Immunohistochemistry & Molecular Morphology, 2020
Ataxia-telangiectasia mutated (ATM), a key activator of DNA damage response mechanisms, represents a potential biomarker for targeted gastric carcinoma therapies. A phase II study (Study 39; NCT01063517) designed to investigate the combination olaparib plus paclitaxel in patients with recurrent or metastatic gastric cancer did not meet its primary ...
Miller, Rachel M., Nworu, Chinedu, McKee, Laurel, Balcerzak, Denis, Pham, Linh, Pugh, Judith, Liu, Yu-Zhen, Gustafson, Heather, Marwah, Ekta, Lamb, Tiffany, Clements, June   +10 more
openaire   +3 more sources

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, EarlyView.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

Procyanidin A1 and its digestive products inhibit acrylamide-induced IPEC-J2 cell damage: apoptosis and cell cycle arrest

Food Science and Human Wellness
Our previous study has demonstrated that procyanidin A1 (A1) and its simulated digestive product (D-A1) can prevent acrylamide (ACR)-induced cytotoxicity in small intestine cells. However, the potential mechanism remains poorly understood. In this study,
Fangfang Yan, Si Qin, Chengming Wang, Wolfram Weckwerth, Qun Lu, Rui Liu   +5 more
doaj   +1 more source

Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability [PDF]

, 2006
DNA damage response mechanisms encompass pathways of DNA repair, cell cycle checkpoint arrest and apoptosis. Together, these mechanisms function to maintain genomic stability in the face of exogenous and endogenous DNA damage.
Ahnesorg, Buck, Calsou, Chappell, Chun, Cui, Difilippantonio, Dore, Fernandez-Capetillo, Frank, Gao, Gladdy, Hefferin, Hirao, Jeggo, Jeggo, Kemp, Kuhne, Kurz, Lavin, Lee, Liu, Lobrich, Lukas, Ma, Markus Löbrich, Moshous, Moshous, Nick McElhinny, Penny A. Jeggo, Poinsignon, Riballo, Rooney, Rothkamm, Stankovic, Stankovic, Terzoudi, Walker, Wang, Weterings, Wyman, Zhang   +41 more
core   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Targeting P53 as a Future Strategy to Overcome Gemcitabine Resistance in Biliary Tract Cancers

Biomolecules, 2020
Gemcitabine-based chemotherapy is the current standard treatment for biliary tract cancers (BTCs) and resistance to gemcitabine remains the clinical challenge.
Chiao-En Wu, Yi-Ru Pan, Chun-Nan Yeh, John Lunec   +3 more
doaj   +1 more source

Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase*

Journal of Biological Chemistry, 2009
ATR (ATM and Rad3-related) initiates a DNA damage signaling pathway in human cells upon DNA damage induced by UV and UV-mimetic agents and in response to inhibition of DNA replication.
L. Lindsey-Boltz, Özdemirhan Serçin, Jun-Hyuk Choi, A. Sancar   +3 more
semanticscholar   +1 more source

The Ataxia Telangiectasia Mutated and Cyclin D3 Proteins Cooperate To Help Enforce TCRβ and IgH Allelic Exclusion [PDF]

The Journal of Immunology, 2014
Abstract Coordination of V rearrangements between loci on homologous chromosomes is critical for Ig and TCR allelic exclusion. The Ataxia Telangietasia mutated (ATM) protein kinase promotes DNA repair and activates checkpoints to suppress aberrant Ig and TCR rearrangements.
Natalie C, Steinel, Megan R, Fisher, Katherine S, Yang-Iott, Craig H, Bassing   +3 more
openaire   +2 more sources

Telomere protein complexes and their role in lymphoid malignancies [PDF]

, 2017
Telomeres are highly regulated and dynamic complexes that protect the genomic DNA and prevent the end of linear chromosomes from being misrecognized as a broken DNA.
Dos Santos, Patricia Carolina, Panero, Julieta, Slavutsky, Irma Rosa   +2 more
core